MIR4467

Summary

MIR4467 (microRNA 4467, HGNC:41896) is a microRNA gene on chromosome 7q22.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616367 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41896
Approved symbol	MIR4467
Name	microRNA 4467
Location	7q22.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4467
Ensembl gene	ENSG00000284596
Ensembl biotype	miRNA
Entrez	100616367
RNAcentral	URS000075B0C8 — ncRNA, 63 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578629

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578629 — 1 exons

Exon	Start	End
ENSE00002685979	102471469	102471531

Expression profiles

Bgee: expression breadth broad, 21 present calls, max score 72.70.

Top tissues by expression

21 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	72.70	gold quality
body of stomach	UBERON:0001161	71.14	gold quality
tibial artery	UBERON:0007610	70.88	gold quality
fundus of stomach	UBERON:0001160	67.86	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.54	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.20	gold quality
blood	UBERON:0000178	66.44	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.49	gold quality
body of uterus	UBERON:0009853	62.44	gold quality
hypothalamus	UBERON:0001898	62.27	gold quality
substantia nigra	UBERON:0002038	60.21	gold quality
skin of abdomen	UBERON:0001416	58.26	gold quality
omental fat pad	UBERON:0010414	57.70	gold quality
left adrenal gland cortex	UBERON:0035825	57.49	gold quality
esophagus mucosa	UBERON:0002469	57.30	gold quality
skin of leg	UBERON:0001511	55.26	gold quality
thoracic mammary gland	UBERON:0005200	52.73	gold quality
transverse colon	UBERON:0001157	52.14	gold quality
spleen	UBERON:0002106	49.62	gold quality
cerebellar hemisphere	UBERON:0002245	45.99	silver quality
caudate nucleus	UBERON:0001873	39.20	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.