MIR4469

Summary

MIR4469 (microRNA 4469, HGNC:41556) is a microRNA gene on chromosome 8p11.21.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616115 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41556
Approved symbol	MIR4469
Name	microRNA 4469
Location	8p11.21
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4469
Ensembl gene	ENSG00000284062
Ensembl biotype	miRNA
Entrez	100616115
RNAcentral	URS000075ABE0 — miRNA, 79 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583919

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583919 — 1 exons

Exon	Start	End
ENSE00002705943	42896197	42896275

Expression profiles

Bgee: expression breadth broad, 89 present calls, max score 81.56.

FANTOM5 (CAGE): breadth broad, TPM avg 1.2627 / max 50.1962, expressed in 841 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
92935	1.2627	841

Top tissues by expression

89 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	81.56	gold quality
calcaneal tendon	UBERON:0003701	79.69	gold quality
adrenal tissue	UBERON:0018303	79.30	gold quality
blood	UBERON:0000178	78.18	gold quality
placenta	UBERON:0001987	77.82	gold quality
right lobe of liver	UBERON:0001114	77.13	gold quality
lymph node	UBERON:0000029	75.23	gold quality
monocyte	CL:0000576	73.98	gold quality
endocervix	UBERON:0000458	73.59	gold quality
gall bladder	UBERON:0002110	73.20	gold quality
gastrocnemius	UBERON:0001388	73.10	gold quality
adult mammalian kidney	UBERON:0000082	71.73	gold quality
liver	UBERON:0002107	71.57	gold quality
right lung	UBERON:0002167	71.57	gold quality
adrenal gland	UBERON:0002369	71.51	gold quality
heart left ventricle	UBERON:0002084	70.16	gold quality
ectocervix	UBERON:0012249	69.64	gold quality
stomach	UBERON:0000945	69.63	gold quality
endometrium	UBERON:0001295	69.02	gold quality
left adrenal gland cortex	UBERON:0035825	68.87	gold quality
urinary bladder	UBERON:0001255	68.78	gold quality
left adrenal gland	UBERON:0001234	68.53	gold quality
heart	UBERON:0000948	68.25	gold quality
right adrenal gland cortex	UBERON:0035827	68.05	gold quality
body of stomach	UBERON:0001161	67.83	gold quality
left coronary artery	UBERON:0001626	67.41	gold quality
right atrium auricular region	UBERON:0006631	67.36	gold quality
tibial artery	UBERON:0007610	67.13	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.93	gold quality
nucleus accumbens	UBERON:0001882	66.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.57

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• LncRNA HCG11 suppresses laryngeal carcinoma cells progression via sponging miR-4469/APOM axis. (PMID:32271435)
• circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene. (PMID:33504681)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.