MIR4470

Summary

MIR4470 (microRNA 4470, HGNC:41833) is a microRNA gene on chromosome 8q12.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616484 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41833
Approved symbol	MIR4470
Name	microRNA 4470
Location	8q12.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4470
Ensembl gene	ENSG00000264408
Ensembl biotype	miRNA
Entrez	100616484
RNAcentral	URS000075EC7E — ncRNA, 72 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583453

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583453 — 1 exons

Exon	Start	End
ENSE00002731747	61714788	61714859

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 83.62.

FANTOM5 (CAGE): breadth broad, TPM avg 1.5474 / max 114.4735, expressed in 391 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
89069	0.9188	274
89070	0.4246	111
89071	0.2039	73

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
vermiform appendix	UBERON:0001154	83.62	gold quality
bone marrow	UBERON:0002371	82.48	gold quality
adult mammalian kidney	UBERON:0000082	81.67	gold quality
monocyte	CL:0000576	80.80	gold quality
calcaneal tendon	UBERON:0003701	79.51	gold quality
body of pancreas	UBERON:0001150	77.86	gold quality
blood	UBERON:0000178	77.67	gold quality
islet of Langerhans	UBERON:0000006	72.50	gold quality
gastrocnemius	UBERON:0001388	71.63	gold quality
heart left ventricle	UBERON:0002084	71.31	gold quality
liver	UBERON:0002107	70.89	gold quality
endometrium	UBERON:0001295	70.36	gold quality
colon	UBERON:0001155	69.92	gold quality
lung	UBERON:0002048	68.96	gold quality
intestine	UBERON:0000160	68.63	gold quality
tibial artery	UBERON:0007610	68.63	gold quality
body of stomach	UBERON:0001161	68.13	gold quality
right lobe of liver	UBERON:0001114	67.41	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.16	gold quality
right adrenal gland	UBERON:0001233	66.63	gold quality
minor salivary gland	UBERON:0001830	66.57	gold quality
left adrenal gland	UBERON:0001234	66.19	gold quality
descending thoracic aorta	UBERON:0002345	66.09	gold quality
left coronary artery	UBERON:0001626	65.95	gold quality
anterior cingulate cortex	UBERON:0009835	65.94	gold quality
left adrenal gland cortex	UBERON:0035825	65.89	gold quality
adipose tissue	UBERON:0001013	65.62	gold quality
omental fat pad	UBERON:0010414	65.49	gold quality
ascending aorta	UBERON:0001496	65.25	gold quality
right hemisphere of cerebellum	UBERON:0014890	64.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Data revealed that the SUCNR1 gene and miRNA-4470 are both expressed in the human retina. miRNA-4470 binds to the 3’UTR of SUCNR1 and regulates its expression. (PMID:31304868)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.