MIR4472-1

Summary

MIR4472-1 (microRNA 4472-1, HGNC:41644) is a microRNA gene on chromosome 8q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616268 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41644
Approved symbol	MIR4472-1
Name	microRNA 4472-1
Location	8q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4472-1
Ensembl gene	ENSG00000265247
Ensembl biotype	miRNA
Entrez	100616268
RNAcentral	URS000075B79B — miRNA, 80 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584349

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584349 — 1 exons

Exon	Start	End
ENSE00002692630	142176339	142176418

Expression profiles

Bgee: expression breadth broad, 56 present calls, max score 79.47.

Top tissues by expression

56 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	79.47	gold quality
heart left ventricle	UBERON:0002084	77.12	gold quality
monocyte	CL:0000576	75.36	gold quality
endocervix	UBERON:0000458	73.70	gold quality
gastrocnemius	UBERON:0001388	71.95	gold quality
thoracic aorta	UBERON:0001515	70.11	gold quality
endometrium	UBERON:0001295	69.91	gold quality
prefrontal cortex	UBERON:0000451	69.84	gold quality
blood	UBERON:0000178	69.62	gold quality
mucosa of stomach	UBERON:0001199	68.22	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.99	gold quality
body of stomach	UBERON:0001161	66.86	gold quality
myometrium	UBERON:0001296	66.74	gold quality
tibial artery	UBERON:0007610	66.44	gold quality
body of uterus	UBERON:0009853	66.44	gold quality
upper lobe of left lung	UBERON:0008952	66.30	gold quality
ectocervix	UBERON:0012249	66.07	gold quality
right atrium auricular region	UBERON:0006631	65.64	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.62	gold quality
muscle layer of sigmoid colon	UBERON:0035805	65.62	gold quality
putamen	UBERON:0001874	65.38	gold quality
right hemisphere of cerebellum	UBERON:0014890	65.38	gold quality
body of pancreas	UBERON:0001150	65.26	gold quality
right lobe of thyroid gland	UBERON:0001119	65.22	gold quality
anterior cingulate cortex	UBERON:0009835	64.77	gold quality
left adrenal gland	UBERON:0001234	64.59	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.51	gold quality
Brodmann (1909) area 9	UBERON:0013540	64.32	gold quality
amygdala	UBERON:0001876	64.13	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MicroRNA-4472 Promotes Tumor Proliferation and Aggressiveness in Breast Cancer by Targeting RGMA and Inducing EMT. (PMID:31899158)
• LncRNA RP11-551L14.4 suppresses breast cancer development by inhibiting the expression of miR-4472. (PMID:36523479)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.