MIR4472-2

Summary

MIR4472-2 (microRNA 4472-2, HGNC:41752) is a microRNA gene on chromosome 12q24.22.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616309 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41752
Approved symbol	MIR4472-2
Name	microRNA 4472-2
Location	12q24.22
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4472-2
Ensembl gene	ENSG00000264037
Ensembl biotype	miRNA
Entrez	100616309
RNAcentral	URS000075C0BB — miRNA, 67 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582069

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582069 — 1 exons

Exon	Start	End
ENSE00002699099	116428252	116428318

Expression profiles

Bgee: expression breadth broad, 69 present calls, max score 89.62.

Top tissues by expression

69 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	89.62	gold quality
adrenal tissue	UBERON:0018303	76.73	gold quality
kidney	UBERON:0002113	76.41	gold quality
liver	UBERON:0002107	73.69	gold quality
blood	UBERON:0000178	73.53	gold quality
monocyte	CL:0000576	73.00	gold quality
gastrocnemius	UBERON:0001388	72.27	gold quality
endometrium	UBERON:0001295	71.99	gold quality
heart left ventricle	UBERON:0002084	71.45	gold quality
substantia nigra	UBERON:0002038	70.63	gold quality
body of pancreas	UBERON:0001150	69.90	gold quality
putamen	UBERON:0001874	69.80	gold quality
heart	UBERON:0000948	69.21	gold quality
body of stomach	UBERON:0001161	68.20	gold quality
popliteal artery	UBERON:0002250	68.14	gold quality
left adrenal gland	UBERON:0001234	68.02	gold quality
tibial artery	UBERON:0007610	67.93	gold quality
stomach	UBERON:0000945	67.80	gold quality
ectocervix	UBERON:0012249	67.72	gold quality
right atrium auricular region	UBERON:0006631	67.23	gold quality
left coronary artery	UBERON:0001626	67.15	gold quality
ascending aorta	UBERON:0001496	67.01	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.89	gold quality
descending thoracic aorta	UBERON:0002345	66.79	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.42	gold quality
lower esophagus	UBERON:0013473	66.37	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.29	gold quality
esophagus mucosa	UBERON:0002469	65.90	gold quality
omental fat pad	UBERON:0010414	65.85	gold quality
Ammon’s horn	UBERON:0001954	65.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• MicroRNA-4472 Promotes Tumor Proliferation and Aggressiveness in Breast Cancer by Targeting RGMA and Inducing EMT. (PMID:31899158)
• LncRNA RP11-551L14.4 suppresses breast cancer development by inhibiting the expression of miR-4472. (PMID:36523479)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.