MIR4473

Summary

MIR4473 (microRNA 4473, HGNC:41540) is a microRNA gene on chromosome 9p21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616229 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41540
Approved symbol	MIR4473
Name	microRNA 4473
Location	9p21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4473
Ensembl gene	ENSG00000263790
Ensembl biotype	miRNA
Entrez	100616229
RNAcentral	URS000075E8F0 — miRNA, 91 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583731

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583731 — 1 exons

Exon	Start	End
ENSE00002733410	20411148	20411238

Expression profiles

Bgee: expression breadth broad, 76 present calls, max score 89.50.

Top tissues by expression

76 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
corpus callosum	UBERON:0002336	89.50	gold quality
kidney	UBERON:0002113	84.79	gold quality
adrenal tissue	UBERON:0018303	84.42	gold quality
blood	UBERON:0000178	83.13	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.77	gold quality
stomach	UBERON:0000945	80.23	gold quality
adult mammalian kidney	UBERON:0000082	77.84	gold quality
calcaneal tendon	UBERON:0003701	76.80	gold quality
heart	UBERON:0000948	75.48	gold quality
placenta	UBERON:0001987	74.11	gold quality
bone marrow	UBERON:0002371	73.83	gold quality
gastrocnemius	UBERON:0001388	72.78	gold quality
lung	UBERON:0002048	71.26	gold quality
monocyte	CL:0000576	71.17	gold quality
left adrenal gland	UBERON:0001234	70.89	gold quality
intestine	UBERON:0000160	70.62	gold quality
heart left ventricle	UBERON:0002084	70.36	gold quality
rectum	UBERON:0001052	70.27	gold quality
body of pancreas	UBERON:0001150	69.71	gold quality
endometrium	UBERON:0001295	69.17	gold quality
body of stomach	UBERON:0001161	68.91	gold quality
right atrium auricular region	UBERON:0006631	68.44	gold quality
liver	UBERON:0002107	68.37	gold quality
colon	UBERON:0001155	68.34	gold quality
substantia nigra	UBERON:0002038	68.22	gold quality
ectocervix	UBERON:0012249	68.00	gold quality
anterior cingulate cortex	UBERON:0009835	67.90	gold quality
endocervix	UBERON:0000458	67.77	gold quality
ascending aorta	UBERON:0001496	67.58	gold quality
thoracic aorta	UBERON:0001515	67.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.