MIR4474

Summary

MIR4474 (microRNA 4474, HGNC:41821) is a microRNA gene on chromosome 9p21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616441 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41821
Approved symbol	MIR4474
Name	microRNA 4474
Location	9p21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4474
Ensembl gene	ENSG00000264941
Ensembl biotype	miRNA
Entrez	100616441
RNAcentral	URS000075CFF2 — ncRNA, 78 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579189

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579189 — 1 exons

Exon	Start	End
ENSE00002708323	20502265	20502342

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 95.58.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	95.58	gold quality
kidney	UBERON:0002113	87.11	gold quality
stomach	UBERON:0000945	78.96	gold quality
monocyte	CL:0000576	78.89	gold quality
blood	UBERON:0000178	78.86	gold quality
adrenal tissue	UBERON:0018303	77.78	gold quality
heart	UBERON:0000948	76.05	gold quality
lung	UBERON:0002048	75.60	gold quality
calcaneal tendon	UBERON:0003701	72.83	gold quality
tibial nerve	UBERON:0001323	72.00	gold quality
endometrium	UBERON:0001295	71.99	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	71.03	gold quality
ascending aorta	UBERON:0001496	70.59	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.39	gold quality
heart left ventricle	UBERON:0002084	68.48	gold quality
intestine	UBERON:0000160	68.21	gold quality
body of stomach	UBERON:0001161	67.29	gold quality
body of uterus	UBERON:0009853	66.47	gold quality
colon	UBERON:0001155	66.29	gold quality
transverse colon	UBERON:0001157	65.38	gold quality
skin of abdomen	UBERON:0001416	65.06	gold quality
amygdala	UBERON:0001876	64.23	gold quality
caudate nucleus	UBERON:0001873	64.22	gold quality
skin of leg	UBERON:0001511	63.79	gold quality
upper lobe of left lung	UBERON:0008952	63.70	gold quality
subcutaneous adipose tissue	UBERON:0002190	63.27	gold quality
left ovary	UBERON:0002119	63.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.23	gold quality
right hemisphere of cerebellum	UBERON:0014890	62.19	gold quality
vagina	UBERON:0000996	61.25	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• High miR4474 expression is associated with colorectal cancer tissues infected with Fusobacterium nucleatum. (PMID:30951563)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.