MIR4475

Summary

MIR4475 (microRNA 4475, HGNC:41697) is a microRNA gene on chromosome 9p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616289 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41697
Approved symbol	MIR4475
Name	microRNA 4475
Location	9p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4475
Ensembl gene	ENSG00000266255
Ensembl biotype	miRNA
Entrez	100616289
RNAcentral	URS000075DCF4 — ncRNA, 61 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580479

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580479 — 1 exons

Exon	Start	End
ENSE00002704976	36823539	36823599

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 74.56.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	74.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.79	gold quality
right frontal lobe	UBERON:0002810	68.32	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	67.08	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.36	gold quality
omental fat pad	UBERON:0010414	66.31	gold quality
skin of leg	UBERON:0001511	65.28	gold quality
lung	UBERON:0002048	64.00	gold quality
left coronary artery	UBERON:0001626	63.06	gold quality
cerebellar hemisphere	UBERON:0002245	60.31	gold quality
left testis	UBERON:0004533	55.00	gold quality
corpus callosum	UBERON:0002336	54.63	gold quality
testis	UBERON:0000473	51.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.