MIR4476

Summary

MIR4476 (microRNA 4476, HGNC:41793) is a microRNA gene on chromosome 9p13.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616456 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41793
Approved symbol	MIR4476
Name	microRNA 4476
Location	9p13.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4476
Ensembl gene	ENSG00000265368
Ensembl biotype	miRNA
Entrez	100616456
RNAcentral	URS000075B8FE — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577752

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577752 — 1 exons

Exon	Start	End
ENSE00002701054	36893462	36893531

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 77.20.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	77.20	gold quality
lymph node	UBERON:0000029	72.54	gold quality
granulocyte	CL:0000094	66.17	gold quality
vagina	UBERON:0000996	66.12	gold quality
omental fat pad	UBERON:0010414	63.26	gold quality
left lobe of thyroid gland	UBERON:0001120	61.79	gold quality
tibial nerve	UBERON:0001323	61.71	gold quality
lung	UBERON:0002048	61.61	gold quality
small intestine Peyer’s patch	UBERON:0003454	60.08	gold quality
spleen	UBERON:0002106	59.46	gold quality
left testis	UBERON:0004533	46.10	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.82

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.