MIR4477A

Summary

MIR4477A (microRNA 4477a, HGNC:41859) is a microRNA gene on chromosome 9p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616184 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41859
Approved symbol	MIR4477A
Name	microRNA 4477a
Location	9p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4477a
Ensembl gene	ENSG00000276029
Ensembl biotype	miRNA
Entrez	100616184
RNAcentral	URS000075D133 — miRNA, 81 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000612572

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000612572 — 1 exons

Exon	Start	End
ENSE00003730986	41233755	41233835

Expression profiles

Bgee: expression breadth ubiquitous, 114 present calls, max score 85.93.

Top tissues by expression

114 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
Ammon’s horn	UBERON:0001954	85.93	gold quality
granulocyte	CL:0000094	85.48	gold quality
cerebellar hemisphere	UBERON:0002245	85.06	gold quality
anterior cingulate cortex	UBERON:0009835	83.81	gold quality
right hemisphere of cerebellum	UBERON:0014890	83.70	gold quality
sural nerve	UBERON:0015488	83.69	gold quality
putamen	UBERON:0001874	83.58	gold quality
leukocyte	CL:0000738	83.09	gold quality
blood	UBERON:0000178	83.00	gold quality
monocyte	CL:0000576	82.98	gold quality
caudate nucleus	UBERON:0001873	82.84	gold quality
substantia nigra	UBERON:0002038	82.84	gold quality
lower esophagus mucosa	UBERON:0035834	82.62	gold quality
nucleus accumbens	UBERON:0001882	82.32	gold quality
cerebral cortex	UBERON:0000956	81.91	gold quality
brain	UBERON:0000955	81.76	gold quality
tonsil	UBERON:0002372	81.64	gold quality
amygdala	UBERON:0001876	81.39	gold quality
corpus callosum	UBERON:0002336	81.07	gold quality
hypothalamus	UBERON:0001898	80.51	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	80.45	gold quality
right frontal lobe	UBERON:0002810	79.81	gold quality
frontal cortex	UBERON:0001870	79.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	78.52	gold quality
spleen	UBERON:0002106	77.81	gold quality
vermiform appendix	UBERON:0001154	77.04	gold quality
endometrium	UBERON:0001295	76.78	gold quality
tibial nerve	UBERON:0001323	76.26	gold quality
bone marrow	UBERON:0002371	75.99	gold quality
duodenum	UBERON:0002114	75.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.68

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.