MIR4478

Summary

MIR4478 (microRNA 4478, HGNC:41759) is a microRNA gene on chromosome 9q33.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616312 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41759
Approved symbol	MIR4478
Name	microRNA 4478
Location	9q33.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4478
Ensembl gene	ENSG00000266583
Ensembl biotype	miRNA
Entrez	100616312
RNAcentral	URS000075CD73 — ncRNA, 86 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584530

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584530 — 1 exons

Exon	Start	End
ENSE00002707983	122120082	122120167

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 76.70.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.70	gold quality
monocyte	CL:0000576	74.93	gold quality
left adrenal gland cortex	UBERON:0035825	74.81	gold quality
left adrenal gland	UBERON:0001234	74.28	gold quality
gastrocnemius	UBERON:0001388	73.91	gold quality
adrenal gland	UBERON:0002369	73.77	gold quality
prefrontal cortex	UBERON:0000451	70.28	gold quality
amygdala	UBERON:0001876	69.87	gold quality
fallopian tube	UBERON:0003889	69.87	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	69.81	gold quality
right adrenal gland cortex	UBERON:0035827	68.86	gold quality
skin of leg	UBERON:0001511	68.76	gold quality
right adrenal gland	UBERON:0001233	68.46	gold quality
endometrium	UBERON:0001295	68.00	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.17	gold quality
ascending aorta	UBERON:0001496	67.10	gold quality
transverse colon	UBERON:0001157	66.79	gold quality
substantia nigra	UBERON:0002038	66.49	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.08	gold quality
Brodmann (1909) area 9	UBERON:0013540	65.27	gold quality
nucleus accumbens	UBERON:0001882	64.56	gold quality
frontal cortex	UBERON:0001870	64.41	gold quality
brain	UBERON:0000955	64.35	gold quality
anterior cingulate cortex	UBERON:0009835	64.10	gold quality
lower esophagus muscularis layer	UBERON:0035833	64.03	gold quality
left ovary	UBERON:0002119	63.74	gold quality
tibial artery	UBERON:0007610	63.69	gold quality
right frontal lobe	UBERON:0002810	63.63	gold quality
tibial nerve	UBERON:0001323	63.61	gold quality
Ammon’s horn	UBERON:0001954	63.39	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.24

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• The expression of miR-4478 and miR-1295b-3p were significantly diminished in stool samples of CRC patients with early stage (I, II) in comparison with normal group. (PMID:25519020)
• The miRNA-448 and 4478 were significantly overexpressed in lung cancer patients (PMID:26341493)
• LINC00461/miR-4478/E2F1 feedback loop promotes non-small cell lung cancer cell proliferation and migration. (PMID:31934717)
• miR-4478 Accelerates Nucleus Pulposus Cells Apoptosis Induced by Oxidative Stress by Targeting MTH1. (PMID:36130054)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.