MIR4479

Summary

MIR4479 (microRNA 4479, HGNC:41767) is a microRNA gene on chromosome 9q34.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616480 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41767
Approved symbol	MIR4479
Name	microRNA 4479
Location	9q34.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4479
Ensembl gene	ENSG00000266507
Ensembl biotype	miRNA
Entrez	100616480
RNAcentral	URS000075D164 — ncRNA, 71 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579420

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579420 — 1 exons

Exon	Start	End
ENSE00002723709	136886733	136886803

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 87.76.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	87.76	gold quality
bone marrow	UBERON:0002371	82.42	gold quality
adrenal tissue	UBERON:0018303	77.94	gold quality
blood	UBERON:0000178	76.99	gold quality
fundus of stomach	UBERON:0001160	75.29	gold quality
liver	UBERON:0002107	75.29	gold quality
muscle of leg	UBERON:0001383	73.70	gold quality
gastrocnemius	UBERON:0001388	73.29	gold quality
urinary bladder	UBERON:0001255	73.27	gold quality
monocyte	CL:0000576	73.09	gold quality
heart left ventricle	UBERON:0002084	72.83	gold quality
adult mammalian kidney	UBERON:0000082	71.79	gold quality
right lobe of liver	UBERON:0001114	71.46	gold quality
heart	UBERON:0000948	71.21	gold quality
endometrium	UBERON:0001295	71.04	gold quality
adenohypophysis	UBERON:0002196	71.03	gold quality
right adrenal gland	UBERON:0001233	70.68	gold quality
left adrenal gland	UBERON:0001234	70.60	gold quality
stomach	UBERON:0000945	70.43	gold quality
left adrenal gland cortex	UBERON:0035825	70.32	gold quality
tibial artery	UBERON:0007610	70.30	gold quality
left uterine tube	UBERON:0001303	69.92	gold quality
adrenal gland	UBERON:0002369	69.83	gold quality
body of stomach	UBERON:0001161	69.79	gold quality
right atrium auricular region	UBERON:0006631	69.44	gold quality
putamen	UBERON:0001874	69.41	gold quality
myometrium	UBERON:0001296	69.33	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.91	gold quality
right hemisphere of cerebellum	UBERON:0014890	68.32	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.26	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.54

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.