MIR4480

Summary

MIR4480 (microRNA 4480, HGNC:41716) is a microRNA gene on chromosome 10p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616151 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41716
Approved symbol	MIR4480
Name	microRNA 4480
Location	10p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4480
Ensembl gene	ENSG00000263584
Ensembl biotype	miRNA
Entrez	100616151
RNAcentral	URS0000759B95 — miRNA, 71 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582492

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582492 — 1 exons

Exon	Start	End
ENSE00002701990	12578753	12578823

Expression profiles

Bgee: expression breadth broad, 63 present calls, max score 84.23.

Top tissues by expression

63 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	84.23	gold quality
blood	UBERON:0000178	82.86	gold quality
liver	UBERON:0002107	81.47	gold quality
adrenal tissue	UBERON:0018303	76.76	gold quality
rectum	UBERON:0001052	75.73	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.37	gold quality
monocyte	CL:0000576	74.68	gold quality
gastrocnemius	UBERON:0001388	73.47	gold quality
Ammon’s horn	UBERON:0001954	72.20	gold quality
body of pancreas	UBERON:0001150	71.81	gold quality
multicellular organism	UBERON:0000468	71.17	gold quality
prefrontal cortex	UBERON:0000451	71.06	gold quality
islet of Langerhans	UBERON:0000006	70.93	gold quality
right lobe of liver	UBERON:0001114	70.12	gold quality
corpus callosum	UBERON:0002336	70.00	gold quality
lung	UBERON:0002048	69.75	gold quality
heart	UBERON:0000948	69.52	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.22	gold quality
stomach	UBERON:0000945	68.82	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.26	gold quality
adrenal gland	UBERON:0002369	68.07	gold quality
body of stomach	UBERON:0001161	68.05	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.04	gold quality
colon	UBERON:0001155	67.74	gold quality
transverse colon	UBERON:0001157	67.67	gold quality
heart left ventricle	UBERON:0002084	67.54	gold quality
right atrium auricular region	UBERON:0006631	67.44	gold quality
intestine	UBERON:0000160	66.93	gold quality
anterior cingulate cortex	UBERON:0009835	66.77	gold quality
skin of abdomen	UBERON:0001416	66.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• serum miR-4428 and miR-4480 may be useful as biomarkers for predicting brain metastasis in patients with breast cancer. (PMID:31603918)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.