MIR4481

Summary

MIR4481 (microRNA 4481, HGNC:41781) is a microRNA gene on chromosome 10p13.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616320 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41781
Approved symbol	MIR4481
Name	microRNA 4481
Location	10p13
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4481
Ensembl gene	ENSG00000283699
Ensembl biotype	miRNA
Entrez	100616320
RNAcentral	URS000075BEB1 — miRNA, 60 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000637781

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000637781 — 1 exons

Exon	Start	End
ENSE00003800413	12653138	12653197

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 86.69.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	86.69	gold quality
vermiform appendix	UBERON:0001154	84.41	gold quality
blood	UBERON:0000178	81.39	gold quality
bone marrow	UBERON:0002371	80.22	gold quality
adult mammalian kidney	UBERON:0000082	79.98	gold quality
myometrium	UBERON:0001296	79.31	gold quality
liver	UBERON:0002107	76.55	gold quality
gastrocnemius	UBERON:0001388	76.06	gold quality
monocyte	CL:0000576	75.25	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.02	gold quality
adrenal gland	UBERON:0002369	72.87	gold quality
stomach	UBERON:0000945	72.77	gold quality
islet of Langerhans	UBERON:0000006	72.68	gold quality
lung	UBERON:0002048	71.62	gold quality
right lobe of liver	UBERON:0001114	71.43	gold quality
substantia nigra	UBERON:0002038	71.16	gold quality
body of pancreas	UBERON:0001150	71.06	gold quality
Ammon’s horn	UBERON:0001954	70.83	gold quality
left adrenal gland	UBERON:0001234	70.62	gold quality
colon	UBERON:0001155	70.11	gold quality
heart	UBERON:0000948	69.89	gold quality
left adrenal gland cortex	UBERON:0035825	69.83	gold quality
ascending aorta	UBERON:0001496	69.75	gold quality
heart left ventricle	UBERON:0002084	69.51	gold quality
tibial artery	UBERON:0007610	69.38	gold quality
intestine	UBERON:0000160	69.18	gold quality
body of stomach	UBERON:0001161	68.95	gold quality
skin of abdomen	UBERON:0001416	68.41	gold quality
right frontal lobe	UBERON:0002810	67.65	gold quality
minor salivary gland	UBERON:0001830	67.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.