MIR4482

Summary

MIR4482 (microRNA 4482, HGNC:41792) is a microRNA gene on chromosome 10q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616323 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41792
Approved symbol	MIR4482
Name	microRNA 4482
Location	10q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4482
Ensembl gene	ENSG00000266852
Ensembl biotype	miRNA
Entrez	100616323
RNAcentral	URS000075F0D2 — miRNA, 70 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583050

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583050 — 1 exons

Exon	Start	End
ENSE00002721778	104268336	104268405

Expression profiles

Bgee: expression breadth ubiquitous, 117 present calls, max score 92.40.

Top tissues by expression

120 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	92.40	gold quality
sural nerve	UBERON:0015488	90.41	gold quality
placenta	UBERON:0001987	89.15	gold quality
vermiform appendix	UBERON:0001154	86.95	gold quality
corpus callosum	UBERON:0002336	86.78	gold quality
rectum	UBERON:0001052	85.70	gold quality
adrenal tissue	UBERON:0018303	85.59	gold quality
bone marrow	UBERON:0002371	85.41	gold quality
duodenum	UBERON:0002114	84.50	gold quality
skeletal muscle tissue	UBERON:0001134	82.71	gold quality
liver	UBERON:0002107	82.26	gold quality
tonsil	UBERON:0002372	81.37	gold quality
monocyte	CL:0000576	80.75	gold quality
leukocyte	CL:0000738	80.52	gold quality
prefrontal cortex	UBERON:0000451	80.12	gold quality
blood	UBERON:0000178	80.11	gold quality
lymph node	UBERON:0000029	79.62	gold quality
islet of Langerhans	UBERON:0000006	79.31	gold quality
right lobe of liver	UBERON:0001114	79.15	gold quality
muscle of leg	UBERON:0001383	79.03	gold quality
gastrocnemius	UBERON:0001388	78.12	gold quality
granulocyte	CL:0000094	77.05	gold quality
endometrium	UBERON:0001295	77.05	gold quality
nucleus accumbens	UBERON:0001882	76.18	gold quality
pancreas	UBERON:0001264	76.01	gold quality
popliteal artery	UBERON:0002250	75.28	gold quality
tibial artery	UBERON:0007610	75.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	75.11	gold quality
anterior cingulate cortex	UBERON:0009835	74.75	gold quality
cerebellar hemisphere	UBERON:0002245	74.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.