MIR4483

Summary

MIR4483 (microRNA 4483, HGNC:41761) is a microRNA gene on chromosome 10q25.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616162 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41761
Approved symbol	MIR4483
Name	microRNA 4483
Location	10q25.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4483
Ensembl gene	ENSG00000283656
Ensembl biotype	miRNA
Entrez	100616162
RNAcentral	URS0000759CBB — miRNA, 62 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000636551

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000636551 — 1 exons

Exon	Start	End
ENSE00003799970	113777993	113778054

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 88.46.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	88.46	gold quality
vermiform appendix	UBERON:0001154	85.17	gold quality
endocervix	UBERON:0000458	82.21	gold quality
blood	UBERON:0000178	78.92	gold quality
saliva-secreting gland	UBERON:0001044	78.35	gold quality
minor salivary gland	UBERON:0001830	78.20	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	77.80	gold quality
body of pancreas	UBERON:0001150	77.02	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.44	gold quality
small intestine	UBERON:0002108	75.24	gold quality
thoracic mammary gland	UBERON:0005200	75.00	gold quality
gastrocnemius	UBERON:0001388	74.89	gold quality
small intestine Peyer’s patch	UBERON:0003454	74.81	gold quality
intestine	UBERON:0000160	73.57	gold quality
islet of Langerhans	UBERON:0000006	73.37	gold quality
endometrium	UBERON:0001295	72.13	gold quality
stomach	UBERON:0000945	71.97	gold quality
rectum	UBERON:0001052	70.96	gold quality
body of stomach	UBERON:0001161	70.00	gold quality
spleen	UBERON:0002106	69.96	gold quality
metanephros cortex	UBERON:0010533	69.29	gold quality
transverse colon	UBERON:0001157	69.16	gold quality
left uterine tube	UBERON:0001303	68.29	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.45	gold quality
right lobe of liver	UBERON:0001114	67.35	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.76	gold quality
adipose tissue	UBERON:0001013	66.60	gold quality
esophagus mucosa	UBERON:0002469	66.14	gold quality
skin of leg	UBERON:0001511	66.11	gold quality
lung	UBERON:0002048	65.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The Role of miR-26a, miR-29a and miR-448-3p in the Development of Cerebral Aneurysm. (PMID:36951025)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.