MIR4484

Summary

MIR4484 (microRNA 4484, HGNC:41799) is a microRNA gene on chromosome 10q26.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616327 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41799
Approved symbol	MIR4484
Name	microRNA 4484
Location	10q26.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4484
Ensembl gene	ENSG00000265092
Ensembl biotype	miRNA
Entrez	100616327
RNAcentral	URS000075AD55 — miRNA, 83 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582855

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582855 — 1 exons

Exon	Start	End
ENSE00002731417	125819740	125819822

Expression profiles

Bgee: expression breadth broad, 75 present calls, max score 80.16.

Top tissues by expression

75 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	80.16	gold quality
bone marrow	UBERON:0002371	79.93	gold quality
blood	UBERON:0000178	78.90	gold quality
substantia nigra	UBERON:0002038	73.71	gold quality
islet of Langerhans	UBERON:0000006	73.61	gold quality
muscle of leg	UBERON:0001383	73.54	gold quality
kidney	UBERON:0002113	72.80	gold quality
monocyte	CL:0000576	72.57	gold quality
gastrocnemius	UBERON:0001388	72.30	gold quality
liver	UBERON:0002107	71.62	gold quality
heart	UBERON:0000948	71.45	gold quality
adult mammalian kidney	UBERON:0000082	71.23	gold quality
corpus callosum	UBERON:0002336	71.20	gold quality
heart left ventricle	UBERON:0002084	71.12	gold quality
right atrium auricular region	UBERON:0006631	71.10	gold quality
endometrium	UBERON:0001295	70.42	gold quality
endocervix	UBERON:0000458	69.67	gold quality
lung	UBERON:0002048	69.51	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	68.95	gold quality
tibial artery	UBERON:0007610	68.94	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.43	gold quality
body of stomach	UBERON:0001161	68.04	gold quality
ascending aorta	UBERON:0001496	67.59	gold quality
left adrenal gland	UBERON:0001234	66.89	gold quality
stomach	UBERON:0000945	66.87	gold quality
rectum	UBERON:0001052	66.84	gold quality
omental fat pad	UBERON:0010414	66.44	gold quality
body of pancreas	UBERON:0001150	66.32	gold quality
minor salivary gland	UBERON:0001830	65.90	gold quality
intestine	UBERON:0000160	65.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.65

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Up-regulation of miR-4484 in nipple discharge is associated with malignant breast cancer. (PMID:25976861)
• miR-4484 was found to be deleted and acts as a tumour suppressor miRNA in Glioblastoma. (PMID:28378523)
• A novel miRNA-4484 is up-regulated on microarray and associated with increased MMP-21 expression in serum of systemic sclerosis patients. (PMID:31582779)
• [MiR-4484 regulates the expression of integrin alpha 6 in gastric cancer tissues and its significance]. (PMID:35316874)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.