MIR4485

Summary

MIR4485 (microRNA 4485, HGNC:41628) is a microRNA gene on chromosome 11p15.4.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616263 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41628
Approved symbol	MIR4485
Name	microRNA 4485
Location	11p15.4
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4485
Ensembl gene	ENSG00000283813
Ensembl biotype	miRNA
Entrez	100616263
RNAcentral	URS000075CEC3 — miRNA, 57 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000638094

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000638094 — 1 exons

Exon	Start	End
ENSE00003800436	10508270	10508326

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 81.56.

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	81.56	gold quality
tibial artery	UBERON:0007610	64.71	gold quality
tibial nerve	UBERON:0001323	61.78	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	46.58	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• This study demonstrated that MIR4485 in patient with major depression disorder was up regulation in peripheral blood mononuclear cells. (PMID:25201637)
• Transfection of a miR-4485 mimic downregulated the expression of regulatory glycolytic pathway genes and reduced the clonogenic ability of breast cancer cells. Levels of both precursor and mature miR-4485 are decreased in tumor tissue. Hence, mitochondria-targeted miR-4485 may act as a tumor suppressor in breast carcinoma cells by negatively regulating mitochondrial RNA processing and mitochondrial functions. (PMID:28220193)
• MiR-4485-3p expression reduced in spermatozoa of men with idiopathic asthenozoospermia. (PMID:32030798)
• SARS-CoV-2-induced Overexpression of miR-4485 Suppresses Osteogenic Differentiation and Impairs Fracture Healing. (PMID:33867845)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.