MIR4486

Summary

MIR4486 (microRNA 4486, HGNC:41566) is a microRNA gene on chromosome 11p15.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616118 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41566
Approved symbol	MIR4486
Name	microRNA 4486
Location	11p15.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4486
Ensembl gene	ENSG00000265210
Ensembl biotype	miRNA
Entrez	100616118
RNAcentral	URS000075E896 — ncRNA, 63 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578325

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578325 — 1 exons

Exon	Start	End
ENSE00002717839	19575310	19575372

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 86.21.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stomach	UBERON:0000945	86.21	gold quality
myometrium	UBERON:0001296	78.98	gold quality
sural nerve	UBERON:0015488	78.07	gold quality
monocyte	CL:0000576	77.33	gold quality
calcaneal tendon	UBERON:0003701	76.05	gold quality
putamen	UBERON:0001874	75.61	gold quality
blood	UBERON:0000178	75.02	gold quality
adult mammalian kidney	UBERON:0000082	74.14	gold quality
gastrocnemius	UBERON:0001388	73.51	gold quality
endometrium	UBERON:0001295	71.75	gold quality
Ammon’s horn	UBERON:0001954	71.14	gold quality
corpus callosum	UBERON:0002336	69.76	gold quality
liver	UBERON:0002107	69.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	69.36	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.72	gold quality
right atrium auricular region	UBERON:0006631	67.53	gold quality
amygdala	UBERON:0001876	66.42	gold quality
tibial artery	UBERON:0007610	66.24	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.91	gold quality
tibial nerve	UBERON:0001323	65.71	gold quality
omental fat pad	UBERON:0010414	64.80	gold quality
upper lobe of left lung	UBERON:0008952	64.72	gold quality
transverse colon	UBERON:0001157	64.33	gold quality
caudate nucleus	UBERON:0001873	64.27	gold quality
thyroid gland	UBERON:0002046	64.21	gold quality
anterior cingulate cortex	UBERON:0009835	64.04	gold quality
skin of leg	UBERON:0001511	63.38	gold quality
left lobe of thyroid gland	UBERON:0001120	62.35	gold quality
hypothalamus	UBERON:0001898	62.16	gold quality
right hemisphere of cerebellum	UBERON:0014890	61.86	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.09

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• LncRNA SNHG20 promoted the proliferation of glioma cells via sponging miR-4486 to regulate the MDM2-p53 pathway. (PMID:31298384)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.