MIR4487

Summary

MIR4487 (microRNA 4487, HGNC:41851) is a microRNA gene on chromosome 11p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616222 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41851
Approved symbol	MIR4487
Name	microRNA 4487
Location	11p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4487
Ensembl gene	ENSG00000264583
Ensembl biotype	miRNA
Entrez	100616222
RNAcentral	URS000075E344 — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582237

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582237 — 1 exons

Exon	Start	End
ENSE00002715146	47400970	47401042

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 78.58.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	78.58	gold quality
prefrontal cortex	UBERON:0000451	77.82	gold quality
bone marrow	UBERON:0002371	75.12	gold quality
muscle of leg	UBERON:0001383	74.98	gold quality
heart left ventricle	UBERON:0002084	74.90	gold quality
monocyte	CL:0000576	73.68	gold quality
gastrocnemius	UBERON:0001388	73.30	gold quality
amygdala	UBERON:0001876	70.31	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.14	gold quality
right ovary	UBERON:0002118	69.05	gold quality
nucleus accumbens	UBERON:0001882	67.75	gold quality
putamen	UBERON:0001874	67.47	gold quality
esophagus mucosa	UBERON:0002469	67.22	gold quality
right atrium auricular region	UBERON:0006631	67.03	gold quality
caudate nucleus	UBERON:0001873	66.80	gold quality
granulocyte	CL:0000094	66.68	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.58	gold quality
right hemisphere of cerebellum	UBERON:0014890	66.20	gold quality
brain	UBERON:0000955	66.08	gold quality
body of stomach	UBERON:0001161	65.91	gold quality
adult mammalian kidney	UBERON:0000082	65.87	gold quality
cerebellar hemisphere	UBERON:0002245	65.70	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.36	gold quality
Ammon’s horn	UBERON:0001954	65.21	gold quality
omental fat pad	UBERON:0010414	64.90	gold quality
substantia nigra	UBERON:0002038	64.88	gold quality
transverse colon	UBERON:0001157	64.81	gold quality
anterior cingulate cortex	UBERON:0009835	64.69	gold quality
adenohypophysis	UBERON:0002196	64.68	gold quality
hypothalamus	UBERON:0001898	64.31	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.38

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• ULK1 could inhibit p70S6K in starvation-induced autophagy, and further identified that miR-4487 and miR-595 were novel ULK1 target miRNAs (PMID:26183158)
• hsa-miR-4487 and hsa-miR-6845-3p contributed to the pathogenesis of AD associated with Abeta25-35 mediated by triggering cell apoptosis and synaptic dysfunction (PMID:30547775)
• MicroRNA-4487 regulates vascular smooth muscle cell proliferation, migration and apoptosis by targeting RAS p21 protein activator 1. (PMID:35483305)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.