MIR4488

Summary

MIR4488 (microRNA 4488, HGNC:41599) is a microRNA gene on chromosome 11q12.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616470 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41599
Approved symbol	MIR4488
Name	microRNA 4488
Location	11q12.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4488
Ensembl gene	ENSG00000266006
Ensembl biotype	miRNA
Entrez	100616470
RNAcentral	URS000075B350 — miRNA, 62 nt, 6 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577388

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577388 — 1 exons

Exon	Start	End
ENSE00002732407	61508596	61508657

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 74.09.

Top tissues by expression

48 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart left ventricle	UBERON:0002084	74.09	gold quality
tibial artery	UBERON:0007610	71.34	gold quality
prostate gland	UBERON:0002367	70.17	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	70.09	gold quality
body of stomach	UBERON:0001161	69.00	gold quality
body of pancreas	UBERON:0001150	68.86	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.77	gold quality
right uterine tube	UBERON:0001302	67.58	gold quality
skin of leg	UBERON:0001511	67.29	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.24	gold quality
right hemisphere of cerebellum	UBERON:0014890	67.06	gold quality
body of uterus	UBERON:0009853	66.86	gold quality
transverse colon	UBERON:0001157	66.84	gold quality
amygdala	UBERON:0001876	66.81	gold quality
thoracic mammary gland	UBERON:0005200	66.58	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.44	gold quality
left ovary	UBERON:0002119	66.38	gold quality
right frontal lobe	UBERON:0002810	65.85	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.82	gold quality
hypothalamus	UBERON:0001898	65.78	gold quality
skin of abdomen	UBERON:0001416	65.76	gold quality
putamen	UBERON:0001874	65.73	gold quality
omental fat pad	UBERON:0010414	65.72	gold quality
cerebral cortex	UBERON:0000956	65.42	gold quality
left coronary artery	UBERON:0001626	65.33	gold quality
anterior cingulate cortex	UBERON:0009835	65.17	gold quality
substantia nigra	UBERON:0002038	64.98	gold quality
small intestine Peyer’s patch	UBERON:0003454	64.87	gold quality
left lobe of thyroid gland	UBERON:0001120	64.78	gold quality
nucleus accumbens	UBERON:0001882	64.63	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.30

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Plasma-Derived Exosomal hsa-miR-4488 and hsa-miR-1228-5p: Novel Biomarkers for Dermatomyositis-Associated Interstitial Lung Disease with Anti-Melanoma Differentiation-Associated Protein 5 Antibody-Positive Subset. (PMID:34368354)
• Identification of a miRNA-based non-invasive predictive biomarker of response to target therapy in BRAF-mutant melanoma. (PMID:36438490)
• Upregulated expression of miR-4443 and miR-4488 in drug resistant melanomas promotes migratory and invasive phenotypes through downregulation of intermediate filament nestin. (PMID:38008717)
• Hypoxic tumor-derived exosomal miR-4488 induces macrophage M2 polarization to promote liver metastasis of pancreatic neuroendocrine neoplasm through RTN3/FABP5 mediated fatty acid oxidation. (PMID:38904015)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.