MIR4489

Summary

MIR4489 (microRNA 4489, HGNC:41685) is a microRNA gene on chromosome 11q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616284 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41685
Approved symbol	MIR4489
Name	microRNA 4489
Location	11q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4489
Ensembl gene	ENSG00000265874
Ensembl biotype	miRNA
Entrez	100616284
RNAcentral	URS000075DFE2 — ncRNA, 62 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578869

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578869 — 1 exons

Exon	Start	End
ENSE00002707714	65649192	65649253

Expression profiles

Bgee: expression breadth ubiquitous, 113 present calls, max score 93.05.

Top tissues by expression

113 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	93.05	gold quality
granulocyte	CL:0000094	93.03	gold quality
blood	UBERON:0000178	92.64	gold quality
spleen	UBERON:0002106	91.49	gold quality
vermiform appendix	UBERON:0001154	90.95	gold quality
duodenum	UBERON:0002114	90.55	gold quality
skeletal muscle tissue	UBERON:0001134	90.51	gold quality
lower esophagus mucosa	UBERON:0035834	87.68	gold quality
bone marrow	UBERON:0002371	85.69	gold quality
monocyte	CL:0000576	84.68	gold quality
lymph node	UBERON:0000029	84.22	gold quality
smooth muscle tissue	UBERON:0001135	84.15	gold quality
tonsil	UBERON:0002372	84.12	gold quality
apex of heart	UBERON:0002098	83.70	gold quality
right lobe of liver	UBERON:0001114	83.66	gold quality
liver	UBERON:0002107	83.04	gold quality
placenta	UBERON:0001987	82.87	gold quality
tibial nerve	UBERON:0001323	81.43	gold quality
prefrontal cortex	UBERON:0000451	80.75	gold quality
endometrium	UBERON:0001295	79.84	gold quality
myometrium	UBERON:0001296	79.77	gold quality
small intestine	UBERON:0002108	79.08	gold quality
heart left ventricle	UBERON:0002084	78.74	gold quality
small intestine Peyer’s patch	UBERON:0003454	78.72	gold quality
upper lobe of left lung	UBERON:0008952	78.31	gold quality
prostate gland	UBERON:0002367	78.25	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	77.98	gold quality
lung	UBERON:0002048	77.96	gold quality
right uterine tube	UBERON:0001302	77.67	gold quality
heart	UBERON:0000948	77.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.