MIR4490

Summary

MIR4490 (microRNA 4490, HGNC:41871) is a microRNA gene on chromosome 11q14.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616186 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41871
Approved symbol	MIR4490
Name	microRNA 4490
Location	11q14.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4490
Ensembl gene	ENSG00000266703
Ensembl biotype	miRNA
Entrez	100616186
RNAcentral	URS000075D402 — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582647

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582647 — 1 exons

Exon	Start	End
ENSE00002726165	90555774	90555857

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 90.77.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	90.77	gold quality
calcaneal tendon	UBERON:0003701	72.35	gold quality
subcutaneous adipose tissue	UBERON:0002190	64.85	gold quality
liver	UBERON:0002107	62.74	gold quality
skin of abdomen	UBERON:0001416	60.36	gold quality
corpus callosum	UBERON:0002336	52.19	gold quality
stomach	UBERON:0000945	48.23	gold quality
left testis	UBERON:0004533	46.20	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.49

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• PSMA6 is post-transcriptionally repressed by the microRNA-4490 in diabetic nephropathy. (PMID:30287505)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.