MIR4491

Summary

MIR4491 (microRNA 4491, HGNC:41808) is a microRNA gene on chromosome 11q23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616330 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41808
Approved symbol	MIR4491
Name	microRNA 4491
Location	11q23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4491
Ensembl gene	ENSG00000264032
Ensembl biotype	miRNA
Entrez	100616330
RNAcentral	URS0000759FFE — miRNA, 68 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581087

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581087 — 1 exons

Exon	Start	End
ENSE00002700424	111347757	111347824

Expression profiles

Bgee: expression breadth broad, 32 present calls, max score 76.21.

Top tissues by expression

32 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	76.21	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.28	gold quality
nucleus accumbens	UBERON:0001882	74.09	gold quality
heart left ventricle	UBERON:0002084	73.71	gold quality
omental fat pad	UBERON:0010414	71.47	gold quality
endometrium	UBERON:0001295	70.76	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	70.44	gold quality
urinary bladder	UBERON:0001255	70.19	gold quality
rectum	UBERON:0001052	69.69	gold quality
body of stomach	UBERON:0001161	69.63	gold quality
tibial artery	UBERON:0007610	68.00	gold quality
ascending aorta	UBERON:0001496	67.72	gold quality
hypothalamus	UBERON:0001898	66.72	gold quality
amygdala	UBERON:0001876	65.54	gold quality
transverse colon	UBERON:0001157	64.43	gold quality
esophagus mucosa	UBERON:0002469	64.33	gold quality
body of uterus	UBERON:0009853	64.20	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.13	gold quality
upper lobe of left lung	UBERON:0008952	64.05	gold quality
spleen	UBERON:0002106	63.89	gold quality
myometrium	UBERON:0001296	63.59	gold quality
minor salivary gland	UBERON:0001830	63.40	gold quality
small intestine Peyer’s patch	UBERON:0003454	63.26	gold quality
skin of leg	UBERON:0001511	63.10	gold quality
caudate nucleus	UBERON:0001873	63.05	gold quality
Ammon’s horn	UBERON:0001954	62.18	gold quality
right frontal lobe	UBERON:0002810	61.51	gold quality
prostate gland	UBERON:0002367	58.96	gold quality
tibial nerve	UBERON:0001323	56.21	gold quality
right testis	UBERON:0004534	43.52	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.17

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Data show that four cardiac fibroblast-derived microRNAS miR-660-3p, miR-665, miR-1285-3p and miR-4491 were found significantly upregulated in heart and plasma during heart failure. (PMID:26683101)
• Depletion of circ-BIRC6, a circular RNA, suppresses non-small cell lung cancer progression by targeting miR-4491. (PMID:33177288)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.