MIR4492

Summary

MIR4492 (microRNA 4492, HGNC:41563) is a microRNA gene on chromosome 11q23.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616376 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41563
Approved symbol	MIR4492
Name	microRNA 4492
Location	11q23.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4492
Ensembl gene	ENSG00000264211
Ensembl biotype	miRNA
Entrez	100616376
RNAcentral	URS000075BCE6 — ncRNA, 80 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581627

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581627 — 1 exons

Exon	Start	End
ENSE00002700420	118910708	118910787

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 76.48.

FANTOM5 (CAGE): breadth broad, TPM avg 1.7166 / max 39.8589, expressed in 568 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
117062	1.7166	568

Top tissues by expression

4 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart	UBERON:0000948	76.48	gold quality
adult mammalian kidney	UBERON:0000082	74.80	gold quality
amygdala	UBERON:0001876	59.44	gold quality
substantia nigra	UBERON:0002038	49.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long noncoding RNA LINC00319 regulates ROMO1 expression and promotes bladder cancer progression via miR-4492/ROMO1 axis. (PMID:31608995)
• IL-17 promotes IL-18 production via the MEK/ERK/miR-4492 axis in osteoarthritis synovial fibroblasts. (PMID:38261743)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.