MIR4494

Summary

MIR4494 (microRNA 4494, HGNC:41731) is a microRNA gene on chromosome 12q13.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616478 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41731
Approved symbol	MIR4494
Name	microRNA 4494
Location	12q13.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4494
Ensembl gene	ENSG00000264906
Ensembl biotype	miRNA
Entrez	100616478
RNAcentral	URS000075B9CB — miRNA, 84 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577654

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577654 — 1 exons

Exon	Start	End
ENSE00002732851	47364186	47364269

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 77.23.

Top tissues by expression

28 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	77.23	gold quality
blood	UBERON:0000178	75.31	gold quality
monocyte	CL:0000576	73.36	gold quality
left adrenal gland	UBERON:0001234	72.62	gold quality
granulocyte	CL:0000094	68.47	gold quality
stomach	UBERON:0000945	66.65	gold quality
omental fat pad	UBERON:0010414	66.51	gold quality
rectum	UBERON:0001052	66.23	gold quality
Ammon’s horn	UBERON:0001954	66.16	gold quality
anterior cingulate cortex	UBERON:0009835	65.43	gold quality
ectocervix	UBERON:0012249	65.04	gold quality
adult mammalian kidney	UBERON:0000082	63.95	gold quality
body of uterus	UBERON:0009853	63.94	gold quality
hypothalamus	UBERON:0001898	63.88	gold quality
right lobe of thyroid gland	UBERON:0001119	63.53	gold quality
amygdala	UBERON:0001876	63.39	gold quality
caudate nucleus	UBERON:0001873	63.15	gold quality
pituitary gland	UBERON:0000007	62.44	gold quality
spleen	UBERON:0002106	62.26	gold quality
fallopian tube	UBERON:0003889	61.57	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	59.16	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	58.70	gold quality
esophagus mucosa	UBERON:0002469	58.66	gold quality
small intestine Peyer’s patch	UBERON:0003454	57.60	gold quality
right uterine tube	UBERON:0001302	57.19	gold quality
nucleus accumbens	UBERON:0001882	57.13	gold quality
prostate gland	UBERON:0002367	56.41	gold quality
left testis	UBERON:0004533	43.28	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.81

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.