MIR4495

Summary

MIR4495 (microRNA 4495, HGNC:41693) is a microRNA gene on chromosome 12q23.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616287 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41693
Approved symbol	MIR4495
Name	microRNA 4495
Location	12q23.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4495
Ensembl gene	ENSG00000265861
Ensembl biotype	miRNA
Entrez	100616287
RNAcentral	URS000075A475 — ncRNA, 66 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577562

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577562 — 1 exons

Exon	Start	End
ENSE00002688860	97939056	97939121

Expression profiles

Bgee: expression breadth tissue_specific, 8 present calls, max score 80.78.

Top tissues by expression

8 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	80.78	gold quality
heart	UBERON:0000948	79.96	gold quality
lower esophagus muscularis layer	UBERON:0035833	71.96	gold quality
body of uterus	UBERON:0009853	65.92	gold quality
tibial nerve	UBERON:0001323	63.45	gold quality
corpus callosum	UBERON:0002336	63.00	gold quality
lung	UBERON:0002048	62.38	gold quality
Brodmann (1909) area 9	UBERON:0013540	60.19	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.41

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• This study demonstrated that MIR4495 in patient with major depression disorder was up regulation in peripheral blood mononuclear cells. (PMID:25201637)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.