MIR4496

Summary

MIR4496 (microRNA 4496, HGNC:41569) is a microRNA gene on chromosome 12q24.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616240 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41569
Approved symbol	MIR4496
Name	microRNA 4496
Location	12q24.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4496
Ensembl gene	ENSG00000284388
Ensembl biotype	miRNA
Entrez	100616240
RNAcentral	URS000075E084 — ncRNA, 61 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635896

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635896 — 1 exons

Exon	Start	End
ENSE00003795302	108635810	108635870

Expression profiles

Bgee: expression breadth broad, 61 present calls, max score 91.40.

Top tissues by expression

61 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lymph node	UBERON:0000029	91.40	gold quality
vermiform appendix	UBERON:0001154	85.67	gold quality
gastrocnemius	UBERON:0001388	76.02	gold quality
blood	UBERON:0000178	75.78	gold quality
monocyte	CL:0000576	74.37	gold quality
stomach	UBERON:0000945	74.18	gold quality
thoracic mammary gland	UBERON:0005200	72.73	gold quality
left adrenal gland cortex	UBERON:0035825	72.53	gold quality
myometrium	UBERON:0001296	71.87	gold quality
tonsil	UBERON:0002372	71.73	gold quality
left adrenal gland	UBERON:0001234	71.16	gold quality
tibial artery	UBERON:0007610	70.93	gold quality
endometrium	UBERON:0001295	70.72	gold quality
Ammon’s horn	UBERON:0001954	69.54	gold quality
adrenal gland	UBERON:0002369	69.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.04	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	68.99	gold quality
nucleus accumbens	UBERON:0001882	68.75	gold quality
heart left ventricle	UBERON:0002084	68.74	gold quality
amygdala	UBERON:0001876	68.59	gold quality
right frontal lobe	UBERON:0002810	68.56	gold quality
gall bladder	UBERON:0002110	68.43	gold quality
right adrenal gland	UBERON:0001233	68.17	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.79	gold quality
cerebellar hemisphere	UBERON:0002245	67.15	gold quality
tibial nerve	UBERON:0001323	66.89	gold quality
right atrium auricular region	UBERON:0006631	66.84	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.83	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.46	gold quality
esophagus mucosa	UBERON:0002469	66.29	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.25

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• CagA is required for increased expression of beta-catenin and its target CIC markers via downregulation of microRNA (miR)-320a and miR-4496. (PMID:28008607)
• Androgen receptor (AR) could negatively regulate the expression of beta-catenin through enhancing the miR-4496 expression via directly binding to the AR-response-elements (AREs) of miR-4496 promoter, subsequently, the miRNA could directly target the 3’ UTR of the beta-catenin-mRNA to reduce its expression. (PMID:30177389)
• CKAP2L Knockdown Exerts Antitumor Effects by Increasing miR-4496 in Glioblastoma Cell Lines. (PMID:33375517)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.