MIR4497

Summary

MIR4497 (microRNA 4497, HGNC:41737) is a microRNA gene on chromosome 12q24.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616454 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41737
Approved symbol	MIR4497
Name	microRNA 4497
Location	12q24.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4497
Ensembl gene	ENSG00000263510
Ensembl biotype	miRNA
Entrez	100616454
RNAcentral	URS000075D15E — miRNA, 89 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583208

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583208 — 1 exons

Exon	Start	End
ENSE00002712967	109833348	109833436

Expression profiles

Bgee: expression breadth broad, 29 present calls, max score 77.18.

Top tissues by expression

29 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
myometrium	UBERON:0001296	77.18	gold quality
monocyte	CL:0000576	73.98	gold quality
blood	UBERON:0000178	72.10	gold quality
adult mammalian kidney	UBERON:0000082	70.88	gold quality
colon	UBERON:0001155	67.92	gold quality
liver	UBERON:0002107	67.80	gold quality
transverse colon	UBERON:0001157	67.64	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.96	gold quality
esophagus mucosa	UBERON:0002469	66.85	gold quality
amygdala	UBERON:0001876	66.76	gold quality
ectocervix	UBERON:0012249	66.20	gold quality
right lobe of liver	UBERON:0001114	65.77	gold quality
body of stomach	UBERON:0001161	65.57	gold quality
omental fat pad	UBERON:0010414	65.23	gold quality
minor salivary gland	UBERON:0001830	64.95	gold quality
vagina	UBERON:0000996	64.60	gold quality
ascending aorta	UBERON:0001496	64.58	gold quality
skin of abdomen	UBERON:0001416	64.06	gold quality
spleen	UBERON:0002106	63.92	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	62.98	gold quality
skin of leg	UBERON:0001511	61.10	gold quality
metanephros cortex	UBERON:0010533	60.35	gold quality
left lobe of thyroid gland	UBERON:0001120	59.12	gold quality
body of uterus	UBERON:0009853	59.05	gold quality
prostate gland	UBERON:0002367	58.86	gold quality
tibial nerve	UBERON:0001323	56.49	gold quality
putamen	UBERON:0001874	55.16	gold quality
left testis	UBERON:0004533	41.92	gold quality
right testis	UBERON:0004534	40.21	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.23

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Results indicate that miR-4497 may play a suppressive role in laryngeal squamous cell carcinoma by targeting GBX2. (PMID:29843929)
• LncRNA FEZF1-AS1 accelerates the migration and invasion of laryngeal squamous cell carcinoma cells through miR-4497 targeting GBX2. (PMID:33550476)
• Down-regulation of the Sp1 transcription factor by an increase of microRNA-4497 in human placenta is associated with early recurrent miscarriage. (PMID:33579314)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.