MIR4498

Summary

MIR4498 (microRNA 4498, HGNC:41838) is a microRNA gene on chromosome 12q24.23.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616179 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41838
Approved symbol	MIR4498
Name	microRNA 4498
Location	12q24.23
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4498
Ensembl gene	ENSG00000266704
Ensembl biotype	miRNA
Entrez	100616179
RNAcentral	URS0000759D9B — ncRNA, 66 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577599

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577599 — 1 exons

Exon	Start	End
ENSE00002700090	120155434	120155499

Expression profiles

Bgee: expression breadth broad, 31 present calls, max score 76.66.

Top tissues by expression

31 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	76.66	gold quality
blood	UBERON:0000178	74.89	gold quality
gastrocnemius	UBERON:0001388	72.80	gold quality
intestine	UBERON:0000160	72.02	gold quality
heart	UBERON:0000948	69.34	gold quality
body of pancreas	UBERON:0001150	68.69	gold quality
subcutaneous adipose tissue	UBERON:0002190	66.79	gold quality
tibial artery	UBERON:0007610	66.13	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	65.95	gold quality
cerebellar hemisphere	UBERON:0002245	65.91	gold quality
omental fat pad	UBERON:0010414	65.54	gold quality
putamen	UBERON:0001874	65.26	gold quality
minor salivary gland	UBERON:0001830	65.14	gold quality
left adrenal gland	UBERON:0001234	65.10	gold quality
transverse colon	UBERON:0001157	64.86	gold quality
vagina	UBERON:0000996	64.66	gold quality
myometrium	UBERON:0001296	64.11	gold quality
testis	UBERON:0000473	63.81	gold quality
left lobe of thyroid gland	UBERON:0001120	63.78	gold quality
esophagus mucosa	UBERON:0002469	63.62	gold quality
skin of leg	UBERON:0001511	62.70	gold quality
tibial nerve	UBERON:0001323	62.25	gold quality
thyroid gland	UBERON:0002046	61.67	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	61.45	gold quality
prostate gland	UBERON:0002367	60.94	gold quality
left ovary	UBERON:0002119	60.65	gold quality
right lobe of thyroid gland	UBERON:0001119	60.38	gold quality
spleen	UBERON:0002106	59.54	gold quality
upper lobe of left lung	UBERON:0008952	59.05	gold quality
Brodmann (1909) area 9	UBERON:0013540	57.99	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• CircSLC7A2 protects against osteoarthritis through inhibition of the miR-4498/TIMP3 axis. (PMID:33960555)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.