MIR4499

Summary

MIR4499 (microRNA 4499, HGNC:41739) is a microRNA gene on chromosome 13q12.11.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616304 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41739
Approved symbol	MIR4499
Name	microRNA 4499
Location	13q12.11
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4499
Ensembl gene	ENSG00000263978
Ensembl biotype	miRNA
Entrez	100616304
RNAcentral	URS000075D859 — ncRNA, 69 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584834

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584834 — 1 exons

Exon	Start	End
ENSE00002710125	20433778	20433846

Expression profiles

Bgee: expression breadth broad, 74 present calls, max score 76.57.

Top tissues by expression

74 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
liver	UBERON:0002107	76.57	gold quality
blood	UBERON:0000178	75.63	gold quality
adult mammalian kidney	UBERON:0000082	74.85	gold quality
kidney	UBERON:0002113	74.63	gold quality
amygdala	UBERON:0001876	74.45	gold quality
fundus of stomach	UBERON:0001160	73.98	gold quality
right lobe of liver	UBERON:0001114	73.34	gold quality
heart left ventricle	UBERON:0002084	72.78	gold quality
right coronary artery	UBERON:0001625	72.75	gold quality
putamen	UBERON:0001874	72.06	gold quality
stomach	UBERON:0000945	72.04	gold quality
descending thoracic aorta	UBERON:0002345	71.41	gold quality
heart	UBERON:0000948	71.28	gold quality
urinary bladder	UBERON:0001255	71.00	gold quality
gastrocnemius	UBERON:0001388	69.80	gold quality
body of stomach	UBERON:0001161	69.46	gold quality
minor salivary gland	UBERON:0001830	69.13	gold quality
endometrium	UBERON:0001295	67.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	67.21	gold quality
tibial artery	UBERON:0007610	67.02	gold quality
esophagus mucosa	UBERON:0002469	66.90	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.87	gold quality
right adrenal gland	UBERON:0001233	66.29	gold quality
ectocervix	UBERON:0012249	66.20	gold quality
caudate nucleus	UBERON:0001873	66.15	gold quality
anterior cingulate cortex	UBERON:0009835	66.05	gold quality
adrenal gland	UBERON:0002369	65.93	gold quality
substantia nigra	UBERON:0002038	65.91	gold quality
lung	UBERON:0002048	65.83	gold quality
ascending aorta	UBERON:0001496	65.66	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.