MIR449C

Summary

MIR449C (microRNA 449c, HGNC:37302) is a microRNA gene on chromosome 5q11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100313923 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:37302
Approved symbol	MIR449C
Name	microRNA 449c
Location	5q11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-449c
Ensembl gene	ENSG00000251856
Ensembl biotype	miRNA
Entrez	100313923
RNAcentral	URS000075D49E — miRNA, 92 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000516047

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000516047 — 1 exons

Exon	Start	End
ENSE00002088324	55172262	55172353

Expression profiles

Bgee: expression breadth broad, 13 present calls, max score 98.49.

Top tissues by expression

13 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	98.49	gold quality
intestine	UBERON:0000160	97.08	gold quality
stomach	UBERON:0000945	78.53	gold quality
lung	UBERON:0002048	75.83	gold quality
heart	UBERON:0000948	74.64	gold quality
right lobe of liver	UBERON:0001114	72.34	gold quality
subcutaneous adipose tissue	UBERON:0002190	67.91	gold quality
cerebellar hemisphere	UBERON:0002245	67.02	gold quality
esophagus mucosa	UBERON:0002469	60.76	gold quality
vagina	UBERON:0000996	55.17	gold quality
right frontal lobe	UBERON:0002810	51.88	gold quality
right testis	UBERON:0004534	46.63	gold quality
left testis	UBERON:0004533	40.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.32

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• Data indicate that 5637 bladder cancer cell line that stably overexpresses microRNA miR-449c is successfully established. (PMID:27371842)
• MicroRNA-449c-5p alleviates lipopolysaccharide-induced HUVECs injury via inhibiting the activation NF-kappab signaling pathway by TAK1. (PMID:35421737)
• miRNA-449c-5p regulates the JAK-STAT pathway in inhibiting cell proliferation and invasion in human breast cancer cells by targeting ERBB2. (PMID:38351535)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.