MIR4500

Summary

MIR4500 (microRNA 4500, HGNC:41853) is a microRNA gene on chromosome 13q31.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616182 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41853
Approved symbol	MIR4500
Name	microRNA 4500
Location	13q31.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4500
Ensembl gene	ENSG00000266052
Ensembl biotype	miRNA
Entrez	100616182
RNAcentral	URS000075BADD — miRNA, 76 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000579472

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000579472 — 1 exons

Exon	Start	End
ENSE00002712928	87618665	87618740

Expression profiles

Bgee: expression breadth broad, 46 present calls, max score 84.24.

Top tissues by expression

46 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	84.24	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.91	gold quality
body of pancreas	UBERON:0001150	70.75	gold quality
anterior cingulate cortex	UBERON:0009835	69.44	gold quality
rectum	UBERON:0001052	68.34	gold quality
stomach	UBERON:0000945	66.08	gold quality
lower esophagus	UBERON:0013473	66.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.84	gold quality
transverse colon	UBERON:0001157	65.79	gold quality
tibial nerve	UBERON:0001323	65.59	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.44	gold quality
right lobe of thyroid gland	UBERON:0001119	65.40	gold quality
cerebral cortex	UBERON:0000956	65.29	gold quality
minor salivary gland	UBERON:0001830	65.13	gold quality
intestine	UBERON:0000160	64.77	gold quality
body of stomach	UBERON:0001161	64.55	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	64.27	gold quality
left coronary artery	UBERON:0001626	64.22	gold quality
omental fat pad	UBERON:0010414	63.99	gold quality
thoracic aorta	UBERON:0001515	63.34	gold quality
muscle layer of sigmoid colon	UBERON:0035805	62.57	gold quality
prostate gland	UBERON:0002367	62.47	gold quality
nucleus accumbens	UBERON:0001882	62.25	gold quality
right frontal lobe	UBERON:0002810	62.00	gold quality
thyroid gland	UBERON:0002046	61.86	gold quality
left lobe of thyroid gland	UBERON:0001120	61.72	gold quality
left uterine tube	UBERON:0001303	61.71	gold quality
fallopian tube	UBERON:0003889	61.60	gold quality
fundus of stomach	UBERON:0001160	61.51	gold quality
Ammon’s horn	UBERON:0001954	61.35	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• Study provides the first evidence that miR-4500 functions as a novel tumor suppressor in the miR-4500/HMGA2 axis in colorectal carcinogenesis. (PMID:27686621)
• miR-4500 inhibits human glioma cell progression by targeting IGF2BP1. (PMID:31000197)
• Results showed that miR-4500 expression was downregulated in papillary thyroid cancer (PTC) and negatively associated with metastasis. Patients with low level of miR-4500 showed a decline trend in overall survival rate after surgery, suggesting miR-4500 could be used as a biomarker for prognosis of PTC patients. miR-4500 inhibits the malignant transformation of PTC cells by directly targeting and repressing PLXNC1. (PMID:31317324)
• Long noncoding RNA NEAT1 modifies cell proliferation, colony formation, apoptosis, migration and invasion via the miR4500/BZW1 axis in ovarian cancer. (PMID:32945505)
• The lncRNA OIP5-AS1/miR-4500 axis targeting ARG2 modulates oxidative stress-induced premature senescence in endothelial cells: implications for vascular aging. (PMID:37203350)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.