MIR4501

Summary

MIR4501 (microRNA 4501, HGNC:41650) is a microRNA gene on chromosome 13q32.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616137 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41650
Approved symbol	MIR4501
Name	microRNA 4501
Location	13q32.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4501
Ensembl gene	ENSG00000283487
Ensembl biotype	miRNA
Entrez	100616137
RNAcentral	URS000075AF1B — ncRNA, 64 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000635771

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000635771 — 1 exons

Exon	Start	End
ENSE00003799314	96427229	96427292

Expression profiles

Bgee: expression breadth broad, 28 present calls, max score 76.32.

Top tissues by expression

28 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lung	UBERON:0002048	76.32	gold quality
gastrocnemius	UBERON:0001388	75.02	gold quality
stomach	UBERON:0000945	72.69	gold quality
monocyte	CL:0000576	72.11	gold quality
myometrium	UBERON:0001296	71.45	gold quality
tibial artery	UBERON:0007610	69.74	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.78	gold quality
right adrenal gland	UBERON:0001233	68.03	gold quality
granulocyte	CL:0000094	67.57	gold quality
skin of abdomen	UBERON:0001416	66.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.47	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.79	gold quality
anterior cingulate cortex	UBERON:0009835	64.98	gold quality
nucleus accumbens	UBERON:0001882	63.89	gold quality
right frontal lobe	UBERON:0002810	62.74	gold quality
intestine	UBERON:0000160	61.74	gold quality
left lobe of thyroid gland	UBERON:0001120	61.58	gold quality
caudate nucleus	UBERON:0001873	61.47	gold quality
skin of leg	UBERON:0001511	61.41	gold quality
putamen	UBERON:0001874	61.16	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	60.32	gold quality
pituitary gland	UBERON:0000007	59.35	gold quality
hypothalamus	UBERON:0001898	59.34	gold quality
Brodmann (1909) area 9	UBERON:0013540	58.59	gold quality
colon	UBERON:0001155	48.87	gold quality
left testis	UBERON:0004533	48.38	gold quality
testis	UBERON:0000473	46.40	gold quality
right testis	UBERON:0004534	39.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.20

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.