MIR4502

Summary

MIR4502 (microRNA 4502, HGNC:41534) is a microRNA gene on chromosome 13q34.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616227 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41534
Approved symbol	MIR4502
Name	microRNA 4502
Location	13q34
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4502
Ensembl gene	ENSG00000265450
Ensembl biotype	miRNA
Entrez	100616227
RNAcentral	URS000075ADA2 — miRNA, 81 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000580432

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000580432 — 1 exons

Exon	Start	End
ENSE00002715778	114273828	114273908

Expression profiles

Bgee: expression breadth ubiquitous, 115 present calls, max score 93.79.

Top tissues by expression

115 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	93.79	gold quality
right uterine tube	UBERON:0001302	93.47	gold quality
left ovary	UBERON:0002119	90.18	gold quality
endometrium	UBERON:0001295	90.12	gold quality
ovary	UBERON:0000992	89.62	gold quality
right ovary	UBERON:0002118	88.89	gold quality
duodenum	UBERON:0002114	88.73	gold quality
right hemisphere of cerebellum	UBERON:0014890	87.99	gold quality
body of pancreas	UBERON:0001150	87.90	gold quality
cerebellar hemisphere	UBERON:0002245	86.97	gold quality
kidney	UBERON:0002113	86.74	gold quality
transverse colon	UBERON:0001157	86.00	gold quality
left lobe of thyroid gland	UBERON:0001120	85.87	gold quality
vermiform appendix	UBERON:0001154	85.78	gold quality
right lobe of thyroid gland	UBERON:0001119	85.72	gold quality
thyroid gland	UBERON:0002046	85.71	gold quality
adult mammalian kidney	UBERON:0000082	85.46	gold quality
skeletal muscle tissue	UBERON:0001134	85.32	gold quality
stomach	UBERON:0000945	85.17	gold quality
small intestine	UBERON:0002108	85.03	gold quality
small intestine Peyer’s patch	UBERON:0003454	84.91	gold quality
pancreas	UBERON:0001264	84.90	gold quality
body of stomach	UBERON:0001161	84.75	gold quality
fundus of stomach	UBERON:0001160	84.43	gold quality
endocervix	UBERON:0000458	84.30	gold quality
mucosa of transverse colon	UBERON:0004991	84.23	gold quality
vagina	UBERON:0000996	84.19	gold quality
intestine	UBERON:0000160	84.17	gold quality
lower esophagus mucosa	UBERON:0035834	84.13	gold quality
skin of abdomen	UBERON:0001416	83.97	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.15

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.