MIR4504

Summary

MIR4504 (microRNA 4504, HGNC:41624) is a microRNA gene on chromosome 14q21.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616261 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41624
Approved symbol	MIR4504
Name	microRNA 4504
Location	14q21.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4504
Ensembl gene	ENSG00000264712
Ensembl biotype	miRNA
Entrez	100616261
RNAcentral	URS000075DFE1 — miRNA, 92 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000577413

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000577413 — 1 exons

Exon	Start	End
ENSE00002710156	50299855	50299946

Expression profiles

Bgee: expression breadth broad, 57 present calls, max score 90.05.

Top tissues by expression

57 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	90.05	gold quality
kidney	UBERON:0002113	85.28	gold quality
blood	UBERON:0000178	75.73	gold quality
heart	UBERON:0000948	74.07	gold quality
body of pancreas	UBERON:0001150	72.80	gold quality
lung	UBERON:0002048	72.45	gold quality
body of stomach	UBERON:0001161	72.43	gold quality
gastrocnemius	UBERON:0001388	71.95	gold quality
intestine	UBERON:0000160	71.21	gold quality
liver	UBERON:0002107	70.57	gold quality
heart left ventricle	UBERON:0002084	70.39	gold quality
Brodmann (1909) area 9	UBERON:0013540	70.19	gold quality
stomach	UBERON:0000945	69.94	gold quality
endometrium	UBERON:0001295	69.71	gold quality
left adrenal gland	UBERON:0001234	69.52	gold quality
urinary bladder	UBERON:0001255	67.72	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.51	gold quality
amygdala	UBERON:0001876	67.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.98	gold quality
colon	UBERON:0001155	66.94	gold quality
ectocervix	UBERON:0012249	66.94	gold quality
omental fat pad	UBERON:0010414	66.63	gold quality
small intestine Peyer’s patch	UBERON:0003454	66.48	gold quality
esophagus mucosa	UBERON:0002469	66.17	gold quality
transverse colon	UBERON:0001157	66.15	gold quality
Ammon’s horn	UBERON:0001954	66.07	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.67	gold quality
skin of leg	UBERON:0001511	64.81	gold quality
vagina	UBERON:0000996	64.67	gold quality
skin of abdomen	UBERON:0001416	64.55	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.99

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.