MIR4505

Summary

MIR4505 (microRNA 4505, HGNC:41743) is a microRNA gene on chromosome 14q24.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616158 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41743
Approved symbol	MIR4505
Name	microRNA 4505
Location	14q24.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4505
Ensembl gene	ENSG00000264741
Ensembl biotype	miRNA
Entrez	100616158
RNAcentral	URS0000759B6A — miRNA, 73 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582238

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582238 — 1 exons

Exon	Start	End
ENSE00002688859	73758747	73758819

Expression profiles

Bgee: expression breadth broad, 82 present calls, max score 96.96.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2393 / max 14.7425, expressed in 103 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
140549	0.2393	103

Top tissues by expression

82 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
sural nerve	UBERON:0015488	96.96	gold quality
calcaneal tendon	UBERON:0003701	85.78	gold quality
lymph node	UBERON:0000029	81.99	gold quality
blood	UBERON:0000178	81.71	gold quality
bone marrow	UBERON:0002371	80.02	gold quality
adult mammalian kidney	UBERON:0000082	79.59	gold quality
adrenal tissue	UBERON:0018303	78.80	gold quality
kidney	UBERON:0002113	78.17	gold quality
liver	UBERON:0002107	77.91	gold quality
monocyte	CL:0000576	76.50	gold quality
granulocyte	CL:0000094	75.41	gold quality
nucleus accumbens	UBERON:0001882	75.08	gold quality
gastrocnemius	UBERON:0001388	73.84	gold quality
stomach	UBERON:0000945	71.20	gold quality
islet of Langerhans	UBERON:0000006	71.17	gold quality
myometrium	UBERON:0001296	70.66	gold quality
tonsil	UBERON:0002372	70.60	gold quality
endometrium	UBERON:0001295	70.41	gold quality
heart left ventricle	UBERON:0002084	70.40	gold quality
right adrenal gland cortex	UBERON:0035827	70.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	69.96	gold quality
right adrenal gland	UBERON:0001233	69.15	gold quality
heart	UBERON:0000948	69.02	gold quality
adrenal gland	UBERON:0002369	68.83	gold quality
substantia nigra	UBERON:0002038	67.95	gold quality
multicellular organism	UBERON:0000468	67.83	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.69	gold quality
tibial artery	UBERON:0007610	67.40	gold quality
body of pancreas	UBERON:0001150	67.30	gold quality
transverse colon	UBERON:0001157	66.71	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.15

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 3)

• miR4505 downregulates the expression of HSPA12B and aggravates the LPSinduced vascular endothelial cell injury. (PMID:29115487)
• Vitamin D receptor-deficient keratinocytes-derived exosomal miR-4505 promotes the macrophage polarization towards the M1 phenotype. (PMID:37554338)
• Identification of plasma miR-4505, miR-4743-5p and miR-4750-3p as novel diagnostic biomarkers for coronary artery disease in patients with type 2 diabetes mellitus: a case-control study. (PMID:39080630)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.