MIR4506

Summary

MIR4506 (microRNA 4506, HGNC:41663) is a microRNA gene on chromosome 14q32.12.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616140 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41663
Approved symbol	MIR4506
Name	microRNA 4506
Location	14q32.12
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4506
Ensembl gene	ENSG00000265768
Ensembl biotype	miRNA
Entrez	100616140
RNAcentral	URS000075A611 — ncRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584693

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584693 — 1 exons

Exon	Start	End
ENSE00002696214	93948226	93948302

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 96.31.

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skeletal muscle tissue	UBERON:0001134	96.31	gold quality
muscle of leg	UBERON:0001383	91.51	gold quality
gastrocnemius	UBERON:0001388	90.94	gold quality
right atrium auricular region	UBERON:0006631	86.61	gold quality
fundus of stomach	UBERON:0001160	83.62	gold quality
myometrium	UBERON:0001296	83.26	gold quality
duodenum	UBERON:0002114	83.20	gold quality
heart	UBERON:0000948	82.78	gold quality
vermiform appendix	UBERON:0001154	82.71	gold quality
muscle layer of sigmoid colon	UBERON:0035805	82.54	gold quality
heart left ventricle	UBERON:0002084	82.52	gold quality
apex of heart	UBERON:0002098	82.18	gold quality
popliteal artery	UBERON:0002250	81.39	gold quality
ascending aorta	UBERON:0001496	81.36	gold quality
tibial artery	UBERON:0007610	81.35	gold quality
endometrium	UBERON:0001295	81.32	gold quality
tonsil	UBERON:0002372	81.22	gold quality
descending thoracic aorta	UBERON:0002345	81.04	gold quality
body of uterus	UBERON:0009853	80.87	gold quality
thoracic aorta	UBERON:0001515	80.85	gold quality
smooth muscle tissue	UBERON:0001135	80.80	gold quality
urinary bladder	UBERON:0001255	80.70	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	79.89	gold quality
lower esophagus	UBERON:0013473	78.84	gold quality
lower esophagus muscularis layer	UBERON:0035833	78.79	gold quality
colon	UBERON:0001155	78.52	gold quality
ectocervix	UBERON:0012249	77.95	gold quality
intestine	UBERON:0000160	77.12	gold quality
stomach	UBERON:0000945	76.64	gold quality
body of stomach	UBERON:0001161	75.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.