MIR4507

Summary

MIR4507 (microRNA 4507, HGNC:41642) is a microRNA gene on chromosome 14q32.33.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616135 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41642
Approved symbol	MIR4507
Name	microRNA 4507
Location	14q32.33
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4507
Ensembl gene	ENSG00000264024
Ensembl biotype	miRNA
Entrez	100616135
RNAcentral	URS000075B6FF — miRNA, 52 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581070

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581070 — 1 exons

Exon	Start	End
ENSE00002732945	105858124	105858175

Expression profiles

Bgee: expression breadth broad, 71 present calls, max score 91.96.

Top tissues by expression

71 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
spleen	UBERON:0002106	91.96	gold quality
anterior cingulate cortex	UBERON:0009835	88.44	gold quality
vermiform appendix	UBERON:0001154	87.25	gold quality
duodenum	UBERON:0002114	86.89	gold quality
lymph node	UBERON:0000029	86.28	gold quality
bone marrow	UBERON:0002371	86.00	gold quality
small intestine Peyer’s patch	UBERON:0003454	85.99	gold quality
small intestine	UBERON:0002108	85.84	gold quality
blood	UBERON:0000178	83.20	gold quality
muscle of leg	UBERON:0001383	80.92	gold quality
mucosa of transverse colon	UBERON:0004991	79.09	gold quality
multicellular organism	UBERON:0000468	78.23	gold quality
transverse colon	UBERON:0001157	78.08	gold quality
stomach	UBERON:0000945	77.89	gold quality
granulocyte	CL:0000094	77.84	gold quality
colon	UBERON:0001155	77.76	gold quality
body of stomach	UBERON:0001161	77.65	gold quality
gall bladder	UBERON:0002110	76.86	gold quality
tonsil	UBERON:0002372	76.74	gold quality
adrenal gland	UBERON:0002369	76.15	gold quality
minor salivary gland	UBERON:0001830	75.98	gold quality
monocyte	CL:0000576	75.89	gold quality
muscle layer of sigmoid colon	UBERON:0035805	75.69	gold quality
pancreas	UBERON:0001264	74.64	gold quality
left uterine tube	UBERON:0001303	74.13	gold quality
right lobe of thyroid gland	UBERON:0001119	73.91	gold quality
fundus of stomach	UBERON:0001160	73.17	gold quality
right lobe of liver	UBERON:0001114	73.15	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	72.97	gold quality
body of pancreas	UBERON:0001150	72.37	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.