MIR4509-2

Summary

MIR4509-2 (microRNA 4509-2, HGNC:41537) is a microRNA gene on chromosome 15q13.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616228 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41537
Approved symbol	MIR4509-2
Name	microRNA 4509-2
Location	15q13.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4509-2
Ensembl gene	ENSG00000266039
Ensembl biotype	miRNA
Entrez	100616228
RNAcentral	URS000075A8B5 — miRNA, 94 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583920

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583920 — 1 exons

Exon	Start	End
ENSE00002722693	28426491	28426584

Expression profiles

Bgee: expression breadth broad, 18 present calls, max score 69.59.

Top tissues by expression

18 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	69.59	gold quality
monocyte	CL:0000576	63.54	gold quality
lower esophagus muscularis layer	UBERON:0035833	62.04	gold quality
adrenal tissue	UBERON:0018303	60.97	gold quality
hypothalamus	UBERON:0001898	59.24	gold quality
right frontal lobe	UBERON:0002810	57.92	gold quality
transverse colon	UBERON:0001157	56.97	gold quality
tibial nerve	UBERON:0001323	54.53	gold quality
putamen	UBERON:0001874	53.55	gold quality
skin of leg	UBERON:0001511	52.38	gold quality
caudate nucleus	UBERON:0001873	51.75	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	49.67	gold quality
Brodmann (1909) area 9	UBERON:0013540	48.22	gold quality
corpus callosum	UBERON:0002336	43.15	silver quality
testis	UBERON:0000473	35.12	silver quality
left testis	UBERON:0004533	35.03	silver quality
lung	UBERON:0002048	33.86	silver quality
right testis	UBERON:0004534	29.10	silver quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.07

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Paralogs (2): MIR4509-3 (ENSG00000263964), MIR4509-1 (ENSG00000276941)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.