MIR450A1

Summary

MIR450A1 (microRNA 450a-1, HGNC:28008) is a microRNA gene on chromosome Xq26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 554214 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28008
Approved symbol	MIR450A1
Name	microRNA 450a-1
Location	Xq26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-450, hsa-mir-450-1, hsa-mir-450a-1
Ensembl gene	ENSG00000199132
Ensembl biotype	miRNA
Entrez	554214
RNAcentral	URS000072EA17 — miRNA, 91 nt, 3 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000362262

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000362262 — 1 exons

Exon	Start	End
ENSE00001437025	134540341	134540431

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 85.53.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	85.53	gold quality
skeletal muscle tissue	UBERON:0001134	83.76	gold quality
intestine	UBERON:0000160	78.09	gold quality
heart	UBERON:0000948	77.40	gold quality
corpus callosum	UBERON:0002336	76.66	gold quality
adult mammalian kidney	UBERON:0000082	76.02	gold quality
muscle of leg	UBERON:0001383	75.42	gold quality
kidney	UBERON:0002113	74.73	gold quality
blood	UBERON:0000178	73.91	gold quality
gastrocnemius	UBERON:0001388	73.53	gold quality
heart left ventricle	UBERON:0002084	72.39	gold quality
lung	UBERON:0002048	72.19	gold quality
muscle layer of sigmoid colon	UBERON:0035805	71.98	gold quality
body of uterus	UBERON:0009853	71.83	gold quality
body of pancreas	UBERON:0001150	71.33	gold quality
liver	UBERON:0002107	71.15	gold quality
myometrium	UBERON:0001296	70.98	gold quality
body of stomach	UBERON:0001161	69.29	gold quality
left adrenal gland	UBERON:0001234	69.18	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.69	gold quality
colon	UBERON:0001155	68.57	gold quality
omental fat pad	UBERON:0010414	68.22	gold quality
Ammon’s horn	UBERON:0001954	68.12	gold quality
transverse colon	UBERON:0001157	68.00	gold quality
tibial artery	UBERON:0007610	67.73	gold quality
fallopian tube	UBERON:0003889	67.36	gold quality
right adrenal gland	UBERON:0001233	67.11	gold quality
esophagus mucosa	UBERON:0002469	67.10	gold quality
left ovary	UBERON:0002119	66.80	gold quality
ascending aorta	UBERON:0001496	66.79	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 5)

• The expression of miRNAs 342 and 450 and NOX-4 activity may help identify those individuals with T2 Diabetes at high risk for developing coronary artery disease (CAD) as well as the prognosis in those with established CAD. (PMID:30681251)
• Tumor necrosis factor alpha (TNF-alpha)-mediated expression of TMEM182 was regulated by miR-450a induction in oral squamous cell carcinoma. MiR-450a-reduced cellular adhesion was abolished by TMEM182 restoration. (PMID:30893332)
• Low miR450A expression is associated with Ovarian Cancer. (PMID:31101765)
• Regulation of cancer stem cell properties, angiogenesis, and vasculogenic mimicry by miR-450a-5p/SOX2 axis in colorectal cancer. (PMID:32144236)
• miR-450a exerts oncosuppressive effects in breast carcinoma by targeting CREB1. (PMID:35451558)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir450-1	ENSMUSG00000065486

Paralogs (2): MIR450A2 (ENSG00000207755), MIR450B (ENSG00000216001)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.