MIR450A2

Summary

MIR450A2 (microRNA 450a-2, HGNC:32137) is a microRNA gene on chromosome Xq26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 574505 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:32137
Approved symbol	MIR450A2
Name	microRNA 450a-2
Location	Xq26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-450-2, hsa-mir-450a-2
Ensembl gene	ENSG00000207755
Ensembl biotype	miRNA
Entrez	574505
RNAcentral	URS000075F0A5 — miRNA, 100 nt, 9 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000385022

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000385022 — 1 exons

Exon	Start	End
ENSE00001500029	134540508	134540607

Expression profiles

Bgee: expression breadth broad, 55 present calls, max score 83.64.

Top tissues by expression

55 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	83.64	gold quality
stomach	UBERON:0000945	80.42	gold quality
adrenal tissue	UBERON:0018303	79.16	gold quality
endometrium	UBERON:0001295	79.15	gold quality
muscle of leg	UBERON:0001383	75.10	gold quality
lung	UBERON:0002048	75.03	gold quality
skin of abdomen	UBERON:0001416	74.24	gold quality
placenta	UBERON:0001987	74.24	gold quality
heart left ventricle	UBERON:0002084	73.17	gold quality
body of stomach	UBERON:0001161	72.99	gold quality
liver	UBERON:0002107	72.80	gold quality
gastrocnemius	UBERON:0001388	72.70	gold quality
right lobe of thyroid gland	UBERON:0001119	72.68	gold quality
myometrium	UBERON:0001296	71.36	gold quality
colon	UBERON:0001155	70.96	gold quality
ovary	UBERON:0000992	70.92	gold quality
left ovary	UBERON:0002119	70.92	gold quality
calcaneal tendon	UBERON:0003701	70.77	gold quality
fallopian tube	UBERON:0003889	70.11	gold quality
urinary bladder	UBERON:0001255	70.06	gold quality
blood	UBERON:0000178	70.03	gold quality
muscle layer of sigmoid colon	UBERON:0035805	69.84	gold quality
lymph node	UBERON:0000029	69.33	gold quality
kidney	UBERON:0002113	68.94	gold quality
intestine	UBERON:0000160	68.71	gold quality
right adrenal gland cortex	UBERON:0035827	68.71	gold quality
transverse colon	UBERON:0001157	68.33	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.28	gold quality
left adrenal gland	UBERON:0001234	67.88	gold quality
hypothalamus	UBERON:0001898	67.56	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.18

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• Tumor necrosis factor alpha (TNF-alpha)-mediated expression of TMEM182 was regulated by miR-450a induction in oral squamous cell carcinoma. MiR-450a-reduced cellular adhesion was abolished by TMEM182 restoration. (PMID:30893332)
• Regulation of cancer stem cell properties, angiogenesis, and vasculogenic mimicry by miR-450a-5p/SOX2 axis in colorectal cancer. (PMID:32144236)
• Exosomes Containing LINC00636 Inhibit MAPK1 through the miR-450a-2-3p Overexpression in Human Pericardial Fluid and Improve Cardiac Fibrosis in Patients with Atrial Fibrillation. (PMID:34257520)
• miR-450a exerts oncosuppressive effects in breast carcinoma by targeting CREB1. (PMID:35451558)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir450-2	ENSMUSG00000076399

Paralogs (2): MIR450A1 (ENSG00000199132), MIR450B (ENSG00000216001)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.