MIR450B

Summary

MIR450B (microRNA 450b, HGNC:33642) is a microRNA gene on chromosome Xq26.3.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100126302 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:33642
Approved symbol	MIR450B
Name	microRNA 450b
Location	Xq26.3
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-450b
Ensembl gene	ENSG00000216001
Ensembl biotype	miRNA
Entrez	100126302
RNAcentral	URS000075C453 — miRNA, 78 nt, 8 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000401182

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000401182 — 1 exons

Exon	Start	End
ENSE00001546526	134540185	134540262

Expression profiles

Bgee: expression breadth broad, 58 present calls, max score 85.07.

Top tissues by expression

58 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endometrium	UBERON:0001295	85.07	gold quality
adrenal tissue	UBERON:0018303	81.46	gold quality
adult mammalian kidney	UBERON:0000082	75.17	gold quality
lung	UBERON:0002048	75.11	gold quality
gastrocnemius	UBERON:0001388	74.45	gold quality
heart	UBERON:0000948	73.64	gold quality
heart left ventricle	UBERON:0002084	72.24	gold quality
islet of Langerhans	UBERON:0000006	72.09	gold quality
placenta	UBERON:0001987	72.06	gold quality
blood	UBERON:0000178	71.98	gold quality
intestine	UBERON:0000160	71.86	gold quality
myometrium	UBERON:0001296	71.76	gold quality
fallopian tube	UBERON:0003889	70.08	gold quality
omental fat pad	UBERON:0010414	69.79	gold quality
left uterine tube	UBERON:0001303	69.74	gold quality
right atrium auricular region	UBERON:0006631	69.15	gold quality
small intestine	UBERON:0002108	68.57	gold quality
right ovary	UBERON:0002118	68.20	gold quality
left adrenal gland	UBERON:0001234	67.53	gold quality
left adrenal gland cortex	UBERON:0035825	67.29	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.29	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.24	gold quality
ovary	UBERON:0000992	67.13	gold quality
esophagus mucosa	UBERON:0002469	66.50	gold quality
body of stomach	UBERON:0001161	66.32	gold quality
left lobe of thyroid gland	UBERON:0001120	66.19	gold quality
thoracic aorta	UBERON:0001515	66.15	gold quality
ascending aorta	UBERON:0001496	65.75	gold quality
left ovary	UBERON:0002119	65.42	gold quality
putamen	UBERON:0001874	65.00	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.05

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 13)

• Data indicate that TGF-beta1 and miR-450b-5p correlated in rhabdomyosarcoma (RMS) tissue. (PMID:23665678)
• miRNA-450b-3p as a new tumor repressor which downregulation with concurrent overexpression of HER3 may serve as a prognostic biomarker for poor overall survival in breast cancer patients. (PMID:25046105)
• Expression of miR-450b-5p was negatively correlated to the expression of SOX2 (PMID:26845645)
• miR-450b-5p induced by oncogenic KRAS is required for colorectal cancer progression (PMID:27494869)
• Confirmation of an oncogenic role for LINC00319 in clinical specimens and cellular experiments, showing the potential LINC00319/miR-450b-5p/EZH2 pathway in lung adenocarcinoma tumorigenesis. (PMID:29408583)
• a novel microRNA miR-450b was essential for adipose-derived mesenchymal stem cell differentiation, which could promote osteogenic differentiation in vitro and enhance bone formation in vivo by directly suppressing BMP3. (PMID:29649414)
• MicroRNA-450b-3p inhibits cell growth by targeting phosphoglycerate kinase 1 in hepatocellular carcinoma. (PMID:31222833)
• The effect of LINC00519-miR-450b-5p-miR-515-5p-YAP1 axis in LUSC. (PMID:32297697)
• Serum ROCK2, miR-300 and miR-450b-5p levels in two different clinical phenotypes of multiple sclerosis: Relation to patient disability and disease progression. (PMID:32781341)
• LncRNA Hoxaas3 promotes lung fibroblast activation and fibrosis by targeting miR-450b-5p to regulate Runx1. (PMID:32848140)
• MIR3142HG promotes lipopolysaccharide-induced acute lung injury by regulating miR-450b-5p/HMGB1 axis. (PMID:34338955)
• Knockdown of hsa_circ_0005699 attenuates inflammation and apoptosis induced by ox-LDL in human umbilical vein endothelial cells through regulation of the miR-450b-5p/NFKB1 axis. (PMID:35904173)
• miR-450b promotes cell migration and invasion by inhibiting SERPINB2 in oral squamous cell carcinoma. (PMID:36251494)

Cross-species orthologs

1 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mir450b	ENSMUSG00000076050

Paralogs (2): MIR450A1 (ENSG00000199132), MIR450A2 (ENSG00000207755)

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.