MIR4510

Summary

MIR4510 (microRNA 4510, HGNC:41708) is a microRNA gene on chromosome 15q14.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616293 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41708
Approved symbol	MIR4510
Name	microRNA 4510
Location	15q14
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4510
Ensembl gene	ENSG00000265098
Ensembl biotype	miRNA
Entrez	100616293
RNAcentral	URS000075A1B3 — miRNA, 68 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578635

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578635 — 1 exons

Exon	Start	End
ENSE00002691023	35926856	35926923

Expression profiles

Bgee: expression breadth broad, 11 present calls, max score 81.10.

Top tissues by expression

11 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
putamen	UBERON:0001874	81.10	gold quality
kidney	UBERON:0002113	80.28	gold quality
blood	UBERON:0000178	77.27	gold quality
lung	UBERON:0002048	73.48	gold quality
thoracic aorta	UBERON:0001515	69.36	gold quality
hypothalamus	UBERON:0001898	67.98	gold quality
left lobe of thyroid gland	UBERON:0001120	65.10	gold quality
liver	UBERON:0002107	60.50	gold quality
corpus callosum	UBERON:0002336	58.25	gold quality
nucleus accumbens	UBERON:0001882	58.20	gold quality
colon	UBERON:0001155	53.46	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.48

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 4)

• miR-4510 blocks hepatocellular carcinoma development through RAF1 targeting and RAS/RAF/MEK/ERK signalling inactivation. (PMID:31612616)
• miR-4510 acts as a tumor suppressor in gastrointestinal stromal tumor by targeting APOC2. (PMID:31975384)
• Identification of miR-4510 as a metastasis suppressor of gastric cancer through regulation of tumor microenvironment via targeting GPC3. (PMID:35050429)
• The profiles of miR-4510 expression level in breast cancer. (PMID:36755123)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.