MIR4511

Summary

MIR4511 (microRNA 4511, HGNC:41589) is a microRNA gene on chromosome 15q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616379 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41589
Approved symbol	MIR4511
Name	microRNA 4511
Location	15q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4511
Ensembl gene	ENSG00000264737
Ensembl biotype	miRNA
Entrez	100616379
RNAcentral	URS000075A281 — miRNA, 87 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000582784

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000582784 — 1 exons

Exon	Start	End
ENSE00002689544	65719246	65719332

Expression profiles

Bgee: expression breadth broad, 60 present calls, max score 82.50.

Top tissues by expression

60 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.50	gold quality
kidney	UBERON:0002113	82.40	gold quality
monocyte	CL:0000576	81.98	gold quality
bone marrow	UBERON:0002371	79.98	gold quality
calcaneal tendon	UBERON:0003701	75.35	gold quality
blood	UBERON:0000178	73.89	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.70	gold quality
heart left ventricle	UBERON:0002084	72.45	gold quality
left adrenal gland	UBERON:0001234	71.46	gold quality
liver	UBERON:0002107	70.72	gold quality
small intestine Peyer’s patch	UBERON:0003454	70.42	gold quality
intestine	UBERON:0000160	70.11	gold quality
adrenal gland	UBERON:0002369	70.03	gold quality
myometrium	UBERON:0001296	69.93	gold quality
left adrenal gland cortex	UBERON:0035825	69.90	gold quality
Brodmann (1909) area 9	UBERON:0013540	69.60	gold quality
endometrium	UBERON:0001295	69.18	gold quality
body of stomach	UBERON:0001161	68.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.80	gold quality
body of pancreas	UBERON:0001150	67.71	gold quality
amygdala	UBERON:0001876	67.25	gold quality
lung	UBERON:0002048	67.21	gold quality
omental fat pad	UBERON:0010414	66.80	gold quality
lower esophagus muscularis layer	UBERON:0035833	66.76	gold quality
ascending aorta	UBERON:0001496	66.52	gold quality
hypothalamus	UBERON:0001898	66.31	gold quality
transverse colon	UBERON:0001157	65.80	gold quality
subcutaneous adipose tissue	UBERON:0002190	65.54	gold quality
minor salivary gland	UBERON:0001830	65.45	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.16	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.78

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.