MIR4512

Summary

MIR4512 (microRNA 4512, HGNC:41701) is a microRNA gene on chromosome 15q22.31.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616149 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41701
Approved symbol	MIR4512
Name	microRNA 4512
Location	15q22.31
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4512
Ensembl gene	ENSG00000266589
Ensembl biotype	miRNA
Entrez	100616149
RNAcentral	URS000075B6F7 — miRNA, 77 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000583257

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000583257 — 1 exons

Exon	Start	End
ENSE00002697215	66496958	66497034

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 93.88.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.88	gold quality
adrenal tissue	UBERON:0018303	82.71	gold quality
vermiform appendix	UBERON:0001154	82.06	gold quality
bone marrow	UBERON:0002371	81.91	gold quality
lymph node	UBERON:0000029	80.15	gold quality
blood	UBERON:0000178	75.44	gold quality
muscle of leg	UBERON:0001383	74.44	gold quality
gastrocnemius	UBERON:0001388	73.21	gold quality
calcaneal tendon	UBERON:0003701	73.00	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	72.65	gold quality
islet of Langerhans	UBERON:0000006	71.82	gold quality
myometrium	UBERON:0001296	71.18	gold quality
endometrium	UBERON:0001295	70.35	gold quality
tonsil	UBERON:0002372	69.56	gold quality
liver	UBERON:0002107	69.18	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.87	gold quality
right atrium auricular region	UBERON:0006631	68.86	gold quality
left adrenal gland cortex	UBERON:0035825	68.86	gold quality
heart left ventricle	UBERON:0002084	68.77	gold quality
stomach	UBERON:0000945	68.44	gold quality
body of pancreas	UBERON:0001150	68.20	gold quality
body of stomach	UBERON:0001161	68.18	gold quality
rectum	UBERON:0001052	67.92	gold quality
anterior cingulate cortex	UBERON:0009835	67.83	gold quality
right adrenal gland	UBERON:0001233	67.35	gold quality
right coronary artery	UBERON:0001625	66.96	gold quality
left adrenal gland	UBERON:0001234	66.90	gold quality
right lobe of liver	UBERON:0001114	66.46	gold quality
popliteal artery	UBERON:0002250	66.40	gold quality
tibial artery	UBERON:0007610	66.36	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.42

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• Decreased miR-4512 Levels in Monocytes and Macrophages of Individuals With Systemic Lupus Erythematosus Contribute to Innate Immune Activation and Neutrsophil NETosis by Targeting TLR4 and CXCL2. (PMID:34721432)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.