MIR4513

Summary

MIR4513 (microRNA 4513, HGNC:41855) is a microRNA gene on chromosome 15q24.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616183 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41855
Approved symbol	MIR4513
Name	microRNA 4513
Location	15q24.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4513
Ensembl gene	ENSG00000264386
Ensembl biotype	miRNA
Entrez	100616183
RNAcentral	URS000075DC63 — miRNA, 86 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581077

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581077 — 1 exons

Exon	Start	End
ENSE00002690338	74788672	74788757

Expression profiles

Bgee: expression breadth broad, 95 present calls, max score 86.32.

Top tissues by expression

95 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow	UBERON:0002371	86.32	gold quality
monocyte	CL:0000576	83.22	gold quality
granulocyte	CL:0000094	82.13	gold quality
blood	UBERON:0000178	81.55	gold quality
adrenal tissue	UBERON:0018303	81.14	gold quality
calcaneal tendon	UBERON:0003701	79.07	gold quality
kidney	UBERON:0002113	77.99	gold quality
lymph node	UBERON:0000029	77.84	gold quality
placenta	UBERON:0001987	76.28	gold quality
fundus of stomach	UBERON:0001160	75.73	gold quality
ectocervix	UBERON:0012249	75.23	gold quality
prefrontal cortex	UBERON:0000451	74.93	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	74.61	gold quality
muscle of leg	UBERON:0001383	74.08	gold quality
stomach	UBERON:0000945	73.60	gold quality
adult mammalian kidney	UBERON:0000082	72.65	gold quality
rectum	UBERON:0001052	72.15	gold quality
smooth muscle tissue	UBERON:0001135	72.09	gold quality
gastrocnemius	UBERON:0001388	72.06	gold quality
islet of Langerhans	UBERON:0000006	71.83	gold quality
endometrium	UBERON:0001295	71.77	gold quality
tonsil	UBERON:0002372	71.28	gold quality
adrenal gland	UBERON:0002369	71.21	gold quality
heart	UBERON:0000948	70.35	gold quality
liver	UBERON:0002107	70.35	gold quality
heart left ventricle	UBERON:0002084	70.09	gold quality
gall bladder	UBERON:0002110	69.99	gold quality
lung	UBERON:0002048	69.51	gold quality
body of pancreas	UBERON:0001150	69.47	gold quality
urinary bladder	UBERON:0001255	69.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.16

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 9)

• findings indicate a pleiotropic effect of miR-4513 on cardiometabolic phenotypes and may improve our understanding of the pathophysiology of cardiometabolic diseases (PMID:25256095)
• Studied microRNA 4513 and microRNA 608 single nucleotide polymorphisms (SNPs) as biomarkers in prognosis and survival in epidermal growth factor receptor targeted tyrosine kinase inhibitor treated lung adenocarcinoma patients and in an in vivo model. (PMID:30552364)
• CT genotype and T allele of microR-4513 rs2168518 is strongly associated with increased susceptibility to coronary artery disease. (PMID:31038082)
• MiR-4513 mediates the proliferation and apoptosis of oral squamous cell carcinoma cells via targeting CXCL17. (PMID:31115009)
• miR-4513 was upregulated in gastric cancer (GC), whereas knockdown of miR-4513 inhibited GC proliferation, invasion, and epithelial-mesenchymal transition. Moreover, we demonstrated that miR-4513 regulates KAT6B expression through direct binding to the 3’-UTR of KAT6B and may serve as a useful therapeutic target for GC. (PMID:31310159)
• Pleiotropic Locus 15q24.1 Reveals a Gender-Specific Association with Neovascular but Not Atrophic Age-Related Macular Degeneration (AMD). (PMID:33050031)
• Long noncoding RNA MEG3 suppresses cell proliferation, migration and invasion, induces apoptosis and paclitaxel-resistance via miR-4513/PBLD axis in breast cancer cells. (PMID:33121324)
• Seed sequence polymorphism rs2168518 and allele-specific target gene regulation of hsa-miR-4513. (PMID:34605899)
• Study the association of microRNA polymorphisms (miR-146a, miR-4513) with the risk of coronary heart diseases in Egyptian population. (PMID:36541377)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.