MIR4514

Summary

MIR4514 (microRNA 4514, HGNC:41845) is a microRNA gene on chromosome 15q25.1.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616181 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41845
Approved symbol	MIR4514
Name	microRNA 4514
Location	15q25.1
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4514
Ensembl gene	ENSG00000265855
Ensembl biotype	miRNA
Entrez	100616181
RNAcentral	URS000075BD59 — ncRNA, 57 nt, 2 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000581410

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000581410 — 1 exons

Exon	Start	End
ENSE00002702587	80997417	80997473

Expression profiles

Bgee: expression breadth broad, 80 present calls, max score 91.56.

Top tissues by expression

80 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
calcaneal tendon	UBERON:0003701	91.56	gold quality
prefrontal cortex	UBERON:0000451	84.23	gold quality
vermiform appendix	UBERON:0001154	83.29	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	82.98	gold quality
adult mammalian kidney	UBERON:0000082	80.07	gold quality
blood	UBERON:0000178	77.01	gold quality
lymph node	UBERON:0000029	76.57	gold quality
muscle of leg	UBERON:0001383	76.50	gold quality
heart left ventricle	UBERON:0002084	74.46	gold quality
monocyte	CL:0000576	73.97	gold quality
gastrocnemius	UBERON:0001388	72.51	gold quality
caudate nucleus	UBERON:0001873	72.36	gold quality
body of pancreas	UBERON:0001150	72.03	gold quality
kidney	UBERON:0002113	71.53	gold quality
stomach	UBERON:0000945	71.50	gold quality
endometrium	UBERON:0001295	71.01	gold quality
rectum	UBERON:0001052	70.70	gold quality
body of stomach	UBERON:0001161	70.60	gold quality
right lobe of liver	UBERON:0001114	69.67	gold quality
lung	UBERON:0002048	69.25	gold quality
liver	UBERON:0002107	69.15	gold quality
left coronary artery	UBERON:0001626	69.05	gold quality
lower esophagus muscularis layer	UBERON:0035833	69.00	gold quality
subcutaneous adipose tissue	UBERON:0002190	68.97	gold quality
right atrium auricular region	UBERON:0006631	68.48	gold quality
thoracic aorta	UBERON:0001515	68.37	gold quality
muscle layer of sigmoid colon	UBERON:0035805	68.34	gold quality
tibial artery	UBERON:0007610	68.25	gold quality
omental fat pad	UBERON:0010414	68.17	gold quality
ascending aorta	UBERON:0001496	68.13	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.34

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.