MIR4515

Summary

MIR4515 (microRNA 4515, HGNC:41800) is a microRNA gene on chromosome 15q25.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616404 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41800
Approved symbol	MIR4515
Name	microRNA 4515
Location	15q25.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4515
Ensembl gene	ENSG00000263643
Ensembl biotype	miRNA
Entrez	100616404
RNAcentral	URS000075CD1B — miRNA, 81 nt, 5 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000584082

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000584082 — 1 exons

Exon	Start	End
ENSE00002687493	83067335	83067415

Expression profiles

Bgee: expression breadth broad, 68 present calls, max score 76.78.

Top tissues by expression

68 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adult mammalian kidney	UBERON:0000082	76.78	gold quality
muscle of leg	UBERON:0001383	75.68	gold quality
prefrontal cortex	UBERON:0000451	75.41	gold quality
gastrocnemius	UBERON:0001388	74.81	gold quality
blood	UBERON:0000178	72.38	gold quality
heart left ventricle	UBERON:0002084	72.06	gold quality
monocyte	CL:0000576	71.63	gold quality
heart	UBERON:0000948	71.63	gold quality
ectocervix	UBERON:0012249	71.24	gold quality
right atrium auricular region	UBERON:0006631	70.63	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	69.49	gold quality
endometrium	UBERON:0001295	68.54	gold quality
left coronary artery	UBERON:0001626	68.54	gold quality
skeletal muscle tissue	UBERON:0001134	68.28	gold quality
left adrenal gland	UBERON:0001234	67.39	gold quality
left adrenal gland cortex	UBERON:0035825	66.86	gold quality
minor salivary gland	UBERON:0001830	66.85	gold quality
frontal cortex	UBERON:0001870	66.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	66.78	gold quality
tibial artery	UBERON:0007610	66.60	gold quality
amygdala	UBERON:0001876	66.22	gold quality
putamen	UBERON:0001874	66.15	gold quality
Brodmann (1909) area 9	UBERON:0013540	66.12	gold quality
body of stomach	UBERON:0001161	66.02	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	65.95	gold quality
body of pancreas	UBERON:0001150	65.91	gold quality
lower esophagus muscularis layer	UBERON:0035833	65.91	gold quality
cerebral cortex	UBERON:0000956	65.78	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	65.75	gold quality
Ammon’s horn	UBERON:0001954	65.64	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.46

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.