MIR4517

Summary

MIR4517 (microRNA 4517, HGNC:41878) is a microRNA gene on chromosome 16p11.2.

microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop.

Source: NCBI Gene 100616487 — RefSeq curated summary.

At a glance

• Gene type: non-coding (miRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41878
Approved symbol	MIR4517
Name	microRNA 4517
Location	16p11.2
Locus type	RNA, micro
Status	Approved
Aliases	hsa-mir-4517
Ensembl gene	ENSG00000284541
Ensembl biotype	miRNA
Entrez	100616487
RNAcentral	URS000075EBD5 — ncRNA, 79 nt, 4 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 miRNA

ENST00000578855

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000578855 — 1 exons

Exon	Start	End
ENSE00002719686	28958583	28958661

Expression profiles

Bgee: expression breadth broad, 20 present calls, max score 76.53.

Top tissues by expression

20 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
duodenum	UBERON:0002114	76.53	gold quality
heart left ventricle	UBERON:0002084	71.96	gold quality
tibial artery	UBERON:0007610	70.65	gold quality
muscle of leg	UBERON:0001383	68.47	gold quality
blood	UBERON:0000178	63.44	gold quality
gastrocnemius	UBERON:0001388	60.98	gold quality
right atrium auricular region	UBERON:0006631	60.71	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	58.47	gold quality
thyroid gland	UBERON:0002046	58.44	gold quality
amygdala	UBERON:0001876	55.28	gold quality
Ammon’s horn	UBERON:0001954	54.26	gold quality
skin of leg	UBERON:0001511	53.25	gold quality
caudate nucleus	UBERON:0001873	53.08	gold quality
putamen	UBERON:0001874	52.60	gold quality
anterior cingulate cortex	UBERON:0009835	51.09	gold quality
brain	UBERON:0000955	51.04	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	50.13	gold quality
cerebellar hemisphere	UBERON:0002245	48.63	silver quality
body of pancreas	UBERON:0001150	45.71	silver quality
substantia nigra	UBERON:0002038	45.69	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.